| Gene Symbol | IRAK2 |
| Full Name | Interleukin-1 Receptor-Associated Kinase 2 |
| Chromosome | 3p25.3 |
| Protein Family | IRAK family (IRAK2) |
| Protein Type | Kinase |
| Function | Receptor activation: Upon TLR or IL-1R activation by pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs), IRAK2 is recruited to the receptor complex through |
| Pathways | NF-κB, MAPK |
| UniProt ID | O43187 |
| NCBI Gene ID | 3656 |
| Ensembl ID | ENSG00000134070 |
| GeneCards | IRAK2 |
| Human Protein Atlas | IRAK2 |
| Residual kinase activity | Low but detectable autophosphorylation capability |
| Scaffolding function | Primary role is as a scaffold for complex assembly |
| Activation loop | Contains an activation loop that can be phosphorylated |
| Associated Diseases | neurodegeneration |
| Interactions | IL1B, IL8 |
| KG Connections | 18 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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