gene 769 words KG: IDH3A
Contents

IDH3A Gene

🧬 Gene Info
Gene SymbolIDH3A
Full NameIsocitrate Dehydrogenase 3 Alpha
Chromosome7q32.2
Protein TypeEnzyme
Functionis a critical mitochondrial enzyme in the tricarboxylic acid (TCA) cycle that plays a pivotal role in cellular energy metabolism.
Subcellular LocalizationMitochondrial matrix
Molecular Weight46 kDa
Amino Acids413 aa
PathwaysAutophagy, Histone Modification
GeneCardsIDH3A
Human Protein AtlasIDH3A
Associated Diseasesneurodegeneration
InteractionsAND, APOPTOSIS, BCL-2, BNIP3, MITOPHAGY, NAD
KG Connections23 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (1)

Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65

Related Analyses (2)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (11)

Cardiac MIBG Scan for Parkinsonism
diagnostic · KG edge: regulates
Neurodegeneration
disease · KG edge: implicated_in
Apoptosis in Neurodegeneration
entity · KG edge: inhibits
Autophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: regulates
nad-augmentation-therapy-early-ad
general · KG edge: inhibits

Knowledge Graph (12 edges)

BNIP3 inhibits IDH3A
TPM1 inhibits IDH3A
IDH3A regulates GAIN
IDH3A inhibits TPM1
IDH3A inhibits BNIP3
MITOPHAGY inhibits IDH3A
APOPTOSIS inhibits IDH3A
AUTOPHAGY regulates IDH3A
BCL-2 inhibits IDH3A
IDH3A inhibits Fibrosis

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