| Gene Symbol | HEATSHOCKPROTEINS |
| Aliases | HEATSHOCKPROTEINS |
| Function | | Family | Members | Primary Function | |
| HSP40 (J-domain proteins) | Deliver substrates to HSP70 and stimulate ATP hydrolysis |
| Nucleotide exchange factors (NEFs) | Promote ADP release, resetting the cycle |
| Inhibit Aβ aggregation | HSP70 and HSP90 directly bind to Aβ peptides, preventing oligomerization and fibril formation (Chaperone, 2024) |
| Promote tau clearance | The HSP70/HSP40/HSP110 complex facilitates the degradation of hyperphosphorylated tau through both proteasomal and autophagic pathways |
| Protect synapses | HSP70 expression in synaptic terminals maintains protein homeostasis during metabolic stress |
| Modulate neuroinflammation | HSP70 can be released from neurons in exosomes, potentially modulating microglial activity |
| Inhibition of α-synuclein aggregation | HSP70 directly binds to α-synuclein, preventing its misfolding and aggregation |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!