gene

KCNK4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNK4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

5Outgoing

1Incoming

0Experiments

0Debates

Summary

Potassium two-pore domain channel gene KCNK4 (TRAAK)

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🧬 Gene Info

Gene Symbol	KCNK4
Aliases	TRAAK, TRAAK Potassium Channel
Function	is a homeostatic excitability regulator.
Molecular Weight	38 kDa
Pathways	Cellular Excitability, Potassium Ion Transport, Temperature Gating
NCBI Gene ID	3778
GeneCards	KCNK4
Human Protein Atlas	KCNK4
Associated Diseases	neurodegeneration
KG Connections	6 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

KCNK4 Gene

gene · 633 words

→

KCNK4 Protein (TRAAK Potassium Channel)

protein · 665 words

→

Pathway Diagram

graph TD
    KCNK4["KCNK4"]
    style KCNK4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    Potassium_Ion_Transport(["Potassium Ion Transport"])
    Cellular_Excitability(["Cellular Excitability"])
    Heat(["Heat"])
    Temperature_Gating(["Temperature Gating"])
    neurodegeneration["neurodegeneration"]

    KCNK4 -->|"involved_in"| Potassium_Ion_Transport
    KCNK4 -->|"regulates"| Cellular_Excitability
    Heat -->|"activates"| KCNK4
    KCNK4 -->|"involved_in"| Temperature_Gating
    KCNK4 -->|"implicated_in"| neurodegeneration

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class Potassium_Ion_Transport protein
    class Cellular_Excitability protein
    class Heat protein
    class Temperature_Gating protein
    class neurodegeneration disease

Outgoing (5)

Target	Relation	Type	Str
potassium leak	mediates	process	0.95
Potassium Ion Transport	involved_in	process	0.95
Cellular Excitability	regulates	process	0.95
Temperature Gating	involved_in	mechanism	0.90
cellular excitability	modulates	phenotype	0.85

Incoming (1)

Source	Relation	Type	Str
Heat	activates	phenotype	0.95

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNK4 in their description or question text

No additional research found