concept

GSK3β

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSK3β: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

2Hypotheses

3Analyses

11Outgoing

17Incoming

0Experiments

3Debates

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💡 Concept Info

Name	GSK3β
Key Genes/Proteins	Akt, AKT, APP, CLCN1, phospho-tau, PI3K
Related Diseases	neurodegeneration
Related Pathways	NF-κB
Linked Hypotheses	2 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

GSK3β (Glycogen Synthase Kinase 3 Beta) Neurons

cell · 590 words

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Pathway Diagram

graph TD
    GSK3_["GSK3beta"]
    GSK3_ -->|"activates"| Tau_hyperphosphorylation["Tau hyperphosphorylation"]
    GSK3_ -->|"activates"| phospho_tau["phospho-tau"]
    GSK3_ -->|"regulates"| Tau["Tau"]
    GSK3_ -->|"inhibits"| PP2A["PP2A"]
    GSK3_ -->|"activates"| PTEN["PTEN"]
    AKT["AKT"] -->|"phosphorylates"| GSK3_
    CLCN1["CLCN1"] -->|"interacts"| GSK3_
    PI3K["PI3K"] -->|"inhibits"| GSK3_
    Akt["Akt"] -->|"regulates"| GSK3_
    exercise["exercise"] -->|"inhibits"| GSK3_
    NRF2["NRF2"] -->|"inhibits"| GSK3_

Outgoing (11)

Target	Relation	Type	Str
h-373fac84b5	targeted_by	hypothesis	1.00
tau	associated_with	protein	0.90
α-Synuclein Pathology	modulates	process	0.80
Complement C3/C3Ar Pathway	involved_in	pathway	0.75
Tau hyperphosphorylation	activates	process	0.70
phospho-tau	activates	protein	0.70
Tau	regulates	protein	0.70
tau hyperphosphorylation	causes	mechanism	0.70
PP2A	inhibits	protein	0.70
PTEN	activates	protein	0.70
neurodegeneration	associated_with	disease	0.43

Incoming (17)

Source	Relation	Type	Str
h-373fac84b5	targets	hypothesis	1.00
PI3K	part_of	gene	0.90
AKT	phosphorylates	protein	0.90
PI3K	interacts_with	gene	0.80
CLCN1	interacts_with	gene	0.80
AKT	regulates	gene	0.80
PI3K	inhibits	pathway	0.80
AKT	inhibits	gene	0.80
Aβ deposition	activates	pathology	0.70
Akt	activates	protein	0.70
exercise	inhibits	process	0.70
Akt	inhibits	protein	0.70
PI3K	regulates	gene	0.70
Akt	regulates	protein	0.70
PTK2B	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
NF-κB	upregulates	pathway	0.50

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
MAP6-CRMPS cooperative phosphorylation by GSK3β	0.700	neurodegeneration	View
GSK3β Inhibition to Prevent α-Synuclein Phosphorylation and	0.429	neurodegeneration	Does RGS6 upregulation or D2 autorecepto