gene

GABRB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABRB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

9Outgoing

6Incoming

0Experiments

0Debates

Summary

GABRB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, expressed in, biomarker for. Associated with Als, Autism, Ms. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	GABA
Full Name	A Receptor Beta 1 Subunit
Chromosome	12p12.3
Function	is a hallmark of neurodegeneration.
Primary Expression	hippocampus, cortex, cerebellum, thalamus, hypothalamus
Amino Acids	602 aa
Exons	14
Pathways	GABAergic Signaling
GeneCards	GABA
Human Protein Atlas	GABA
Associated Diseases	Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	rapamycin
Interactions	ABCA7, ACTB, Actin, Akt, AKT, AKT1
KG Connections	1381 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: GABRB1 — AlphaFold P18505 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GABA-A Receptor Beta 1 Subunit

gene · 828 words

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Pathway Diagram

graph TD
    GABRB1["GABRB1"]
    Als{"Als"}
    GABRB1 -->|"biomarker for"| Als
    Autism{"Autism"}
    GABRB1 -->|"biomarker for"| Autism
    Ms{"Ms"}
    GABRB1 -->|"biomarker for"| Ms
    GABRB1 -->|"associated with"| Ms
    Schizophrenia{"Schizophrenia"}
    GABRB1 -->|"associated with"| Schizophrenia
    GABARAP["GABARAP"]
    GABRB1 -->|"expressed in"| GABARAP
    Toll_Like_Receptor(["Toll-Like Receptor"])
    GABRB1 -->|"associated with"| Toll_Like_Receptor
    neurodegeneration["neurodegeneration"]
    GABRB1 -->|"implicated in"| neurodegeneration
    GABARAPL1["GABARAPL1"]
    GABARAPL1 -->|"expressed in"| GABRB1
    GABARAP -->|"expressed in"| GABRB1
    GRM5["GRM5"]
    GRM5 -->|"associated with"| GABRB1
    GABARAP -->|"associated with"| GABRB1
    style GABRB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (9)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:GABRB1	data_in	dataset_row	0.00
ds-83b31ef18d49	provides_data_for	dataset	1.00
Als	biomarker_for	disease	0.65
Autism	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Ms	associated_with	disease	0.65
Schizophrenia	associated_with	disease	0.65
Toll-Like Receptor	associated_with	pathway	0.60
GABARAP	expressed_in	gene	0.60

Incoming (6)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:GABRB1	data_in	dataset_row	0.00
ds-83b31ef18d49	data_in	dataset	1.00
GABARAPL1	expressed_in	gene	0.60
GABARAP	expressed_in	gene	0.60
GRM5	associated_with	gene	0.60
GABARAP	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning GABRB1 in their description or question text

No additional research found