gene

EPHA8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EPHA8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

20Outgoing

10Incoming

0Experiments

0Debates

Summary

Ephrin Type-A Receptor 8, a receptor tyrosine kinase involved in neuronal development, axon guidance, and cognitive function

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🧬 Gene Info

Gene Symbol	EPHA8
Full Name	Ephrin Type-A Receptor 8
Chromosome	1p36.22.
Protein Type	Receptor
Function	Hippocampal Function: EPHA8 is highly expressed in CA1 pyramidal neurons where it regulates synaptic plasticity and spatial memory formation[@li2019].
Primary Expression	Pyramidal neurons, Interneurons, Glia
Molecular Weight	105 kDa
Amino Acids	986 aa
Exons	18
UniProt ID	Q9Y232
NCBI Gene ID	2045
Ensembl ID	ENSG00000077312
OMIM	603306
GeneCards	EPHA8
Human Protein Atlas	EPHA8
Associated Diseases	Alzheimer's Disease, Parkinson's Disease
KG Connections	30 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: EPHA8 — AlphaFold Q9Y232 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

EPHA8 Gene

gene · 3199 words

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Pathway Diagram

graph TD
    EPHA8["EPHA8"]
    Als{"Als"}
    EPHA8 -->|"regulates"| Als
    Cancer{"Cancer"}
    EPHA8 -->|"regulates"| Cancer
    ALS{"ALS"}
    EPHA8 -->|"regulates"| ALS
    P38(["P38"])
    EPHA8 -->|"associated_with"| P38
    GSK3(["GSK3"])
    EPHA8 -->|"associated_with"| GSK3
    Neuron["Neuron"]
    EPHA8 -->|"regulates"| Neuron
    LRRN1(["LRRN1"])
    LRRN1 -->|"regulates"| EPHA8
    ERK1(["ERK1"])
    ERK1 -->|"associated_with"| EPHA8
    PI3K(["PI3K"])
    PI3K -->|"associated_with"| EPHA8
    NEURON(["NEURON"])
    NEURON -->|"regulates"| EPHA8
    style EPHA8 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (20)

Target	Relation	Type	Str
ALS	regulates	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
GSK3	associated_with	gene	0.60
NEURON	regulates	gene	0.60
CANCER	regulates	gene	0.60
Neuron	regulates	cell_type	0.60
AND	associated_with	gene	0.60
Interferon	regulates	protein	0.60
Cytokine	regulates	protein	0.60
Erk	associated_with	protein	0.60
Fgf	associated_with	protein	0.60
Ras	regulates	protein	0.60
PI3K	associated_with	gene	0.60
ERK1	associated_with	gene	0.60
LRRN1	regulates	gene	0.60
P38	associated_with	gene	0.60
SMPD1	regulates	gene	0.60
Neuron	expressed_in	cell_type	0.55
Proteins	associated_with	protein	0.50

Incoming (10)

Source	Relation	Type	Str
NEURON	regulates	gene	0.60
GSK3	associated_with	gene	0.60
GAIN	regulates	gene	0.60
P38	associated_with	gene	0.60
LRRN1	regulates	gene	0.60
ERK1	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
SMPD1	regulates	gene	0.60
PKC	associated_with	gene	0.60
Pi3K	associated_with	pathway	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning EPHA8 in their description or question text

No additional research found