gene 3,199 words KG: EPHA8
Contents

EPHA8 Gene

🧬 Gene Info
Gene SymbolEPHA8
Full NameEphrin Type-A Receptor 8
Chromosome1p36.22.
Protein TypeReceptor
FunctionHippocampal Function: EPHA8 is highly expressed in CA1 pyramidal neurons where it regulates synaptic plasticity and spatial memory formation[@li2019].
Primary ExpressionPyramidal neurons, Interneurons, Glia
Molecular Weight105 kDa
Amino Acids986 aa
Exons18
UniProt IDQ9Y232
NCBI Gene ID2045
Ensembl IDENSG00000077312
OMIM603306
GeneCardsEPHA8
Human Protein AtlasEPHA8
Associated DiseasesAlzheimer's Disease, Parkinson's Disease
KG Connections30 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
APOE-Dependent Autophagy Restoration
Score: 0.85
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69

Related Analyses (4)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (12)

NeuRon Therapeutics
company · KG edge: regulates
ERK1 (MAPK3) — Extracellular Signal-Regulated Kinase 1
gene · KG edge: associated_with
LRRN1 — Leucine Rich Repeat Neuronal 1
gene · KG edge: regulates
PI3K — Phosphoinositide 3-Kinase
gene · KG edge: associated_with
SMPD1 Gene - Acid Sphingomyelinase
gene · KG edge: regulates

Knowledge Graph (12 edges)

LRRN1 regulates EPHA8
ERK1 associated_with EPHA8
PI3K associated_with EPHA8
SMPD1 regulates EPHA8
PKC associated_with EPHA8
EPHA8 associated_with P38
GAIN regulates EPHA8
EPHA8 associated_with PI3K
EPHA8 associated_with ERK1
EPHA8 regulates LRRN1

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