gene

DLG2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLG2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

20Outgoing

13Incoming

0Experiments

0Debates

Summary

Page for DLG2 Gene

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🧬 Gene Info

Gene Symbol	DLG2
Chromosome	11q14.1
Protein Type	Scaffold Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the postsynaptic density of excitatory synapses
Pathways	PI3K, MAPK signaling
UniProt ID	Q9UQB8
NCBI Gene ID	1749
Ensembl ID	ENSG00000150672
GeneCards	DLG2
Human Protein Atlas	DLG2
SH3 domain	Binds to proline-rich motifs in proteins like AKAP5
Guanylate kinase (GK) domain	Associates with GKAP/SAPAP proteins, linking to Homer and Shank complexes
Associated Diseases	neurodegeneration
Interactions	APOE, APP, BIN1, NR3C2, PICALM, PTK2B
KG Connections	33 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DLG2 — AlphaFold Q9UQB8 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

DLG2 Gene

gene · 855 words

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Pathway Diagram

graph TD
    DLG2["DLG2"]
    Alzheimer["Alzheimer"]
    DLG2 -->|"regulates"| Alzheimer
    Als["Als"]
    DLG2 -->|"regulates"| Als
    ALS["ALS"]
    DLG2 -->|"regulates"| ALS
    TAU["TAU"]
    DLG2 -->|"regulates"| TAU
    APOE["APOE"]
    DLG2 -->|"contributes to"| APOE
    BIN1["BIN1"]
    DLG2 -->|"contributes to"| BIN1
    SYNAPSE["SYNAPSE"]
    DLG2 -->|"regulates"| SYNAPSE
    PTK2B["PTK2B"]
    DLG2 -->|"contributes to"| PTK2B
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    DLG2 -->|"regulates"| ALZHEIMER_S_DISEASE
    PICALM["PICALM"]
    DLG2 -->|"contributes to"| PICALM
    Glutamate_Signaling["Glutamate Signaling"]
    DLG2 -->|"contributes to"| Glutamate_Signaling
    PICALM["PICALM"]
    PICALM -->|"contributes to"| DLG2
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"regulates"| DLG2
    APP["APP"]
    APP -->|"regulates"| DLG2
    SYNAPSE["SYNAPSE"]
    SYNAPSE -->|"regulates"| DLG2
    GENES["GENES"]
    GENES -->|"regulates"| DLG2
    PTK2B["PTK2B"]
    PTK2B -->|"contributes to"| DLG2
    APOE["APOE"]
    APOE -->|"contributes to"| DLG2
    TAU["TAU"]
    TAU -->|"regulates"| DLG2
    BIN1["BIN1"]
    BIN1 -->|"contributes to"| DLG2
    AND["AND"]
    AND -->|"contributes to"| DLG2
    neurodegeneration["neurodegeneration"]
    DLG2 -->|"implicated in"| neurodegeneration

Outgoing (20)

Target	Relation	Type	Str
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
NR3C2	activates	gene	0.60
PICALM	interacts_with	gene	0.60
glutamate signaling	participates_in	pathway	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
Glutamate Signaling	contributes_to	pathway	0.60
TAU	regulates	gene	0.60
APOE	contributes_to	gene	0.60
BIN1	contributes_to	gene	0.60
PTK2B	contributes_to	gene	0.60
PICALM	contributes_to	gene	0.60
SYNAPSE	regulates	gene	0.60
APP	regulates	gene	0.60
Aβ	regulates	protein	0.60
GLUTAMATE	interacts_with	concept	0.50
Glutamate Signaling	interacts_with	pathway	0.50
PTK2B	interacts_with	gene	0.50
BIN1	interacts_with	gene	0.50

Incoming (13)

Source	Relation	Type	Str
APP	interacts_with	gene	0.60
BIN1	interacts_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
GENES	regulates	gene	0.60
PICALM	contributes_to	gene	0.60
APP	regulates	gene	0.60
PTK2B	contributes_to	gene	0.60
APOE	contributes_to	gene	0.60
TAU	regulates	gene	0.60
BIN1	contributes_to	gene	0.60
APOE	interacts_with	gene	0.50
PICALM	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning DLG2 in their description or question text

No additional research found