Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BDNF, CREB1, synaptic plasticity genes: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:BDNF, CREB1, SYNAPTIC PLASTICITY GENES | data_in | dataset_row | 0.00 |
| Cell-type-specific essential genes | debate_co_mention | gene | 0.45 |
| Disease-causing mutations with integrated reporters | debate_co_mention | gene | 0.45 |
| HMGCR, LDLR, APOE regulatory regions | debate_co_mention | gene | 0.45 |
| HTT, DMPK, repeat-containing transcripts | debate_co_mention | gene | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:BDNF, CREB1, SYNAPTIC PLASTICITY GENES | data_in | dataset_row | 0.00 |
| APOE | debate_co_mention | gene | 0.45 |
| BDNF | debate_co_mention | gene | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Epigenetic Memory Reprogramming for Alzheimer's Disease | 0.611 | neurodegeneration | CRISPR-based therapeutic approaches for |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Targeting synaptic plasticity and acetylcholine dysregulation in the medial pref [PMID:41014339] | Shi J, Chen M, Zhang Y, Fan X, Wang L et | Psychopharmacology (Berl) | 2026 | 0 |
| The physiopathology of brain-derived neurotrophic factor. [PMID:40490314] | Barde YA | Physiological reviews | 2025 | 0 |
| BDNF-enriched small extracellular vesicles protect against noise-induced hearing [PMID:37939851] | ["Min X", "Deng X", "Lao H", "Wu Z", "Ch | Journal of controlled release | 2023 | 0 |
| Butyrate ameliorates quinolinic acid-induced cognitive decline in obesity models [PMID:36787221] | Ge X, Zheng M, Hu M, Fang X, Geng D, Liu | The Journal of clinical invest | 2023 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Future rice farming threatened by drought in the Lower Mekong Basin. [PMID:33931657] | Kang H, Sridhar V, Mainuddin M, Trung LD | Scientific reports | 2021 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| Sex differences in myelin content of white matter tracts in adolescents with dep [PMID:34215842] | Ho TC, Sisk LM, Kulla A, Teresi GI, Hans | Neuropsychopharmacology : offi | 2021 | 0 |
| Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in D [PMID:33096634] | ["Colucci-D'Amato L", "Speranza L", "Vol | International journal of molec | 2020 | 0 |
| Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in D [PMID:33096634] | Colucci-D'Amato L, Speranza L, Volpicell | Int J Mol Sci | 2020 | 0 |
| Targeting BDNF signaling by natural products: Novel synaptic repair therapeutics [PMID:31546015] | ["Bawari S", "Tewari D", "Arg\u00fcelles | Pharmacological research | 2019 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning BDNF, CREB1, synaptic plasticity genes in their description or question text
No additional research found