Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PGC1A, SIRT1, FOXO3, MITOCHONDRIAL BIOGENESIS GENES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PGC1A, SIRT1, FOXO3, MITOCHONDRIAL BIOGENESIS GENES |
graph TD
PGC1A__SIRT1__FOXO3__MITOCHOND[PGC1A, SIRT1, FOXO3, MITOCHONDRIAL BIOGENESIS GENES]
PGC1A__SIRT1__FOXO3__MITOCHOND -->|debate_co_mention| RANK[RANK]
PGC1A__SIRT1__FOXO3__MITOCHOND -->|debate_co_mention| SIRT1[SIRT1]
PGC1A__SIRT1__FOXO3__MITOCHOND -->|debate_co_mention| RNA[RNA]
PGC1A__SIRT1__FOXO3__MITOCHOND -->|implicated in| neurodegeneration[neurodegeneration]
PGC1A__SIRT1__FOXO3__MITOCHOND -->|co_associated_with| CRISPR[CRISPR]
h_827a821b[h-827a821b] -->|targets| PGC1A__SIRT1__FOXO3__MITOCHOND
Disease_causing_mutations_with[Disease-causing mutations with integrated reporters] -->|debate_co_mention| PGC1A__SIRT1__FOXO3__MITOCHOND
HMGCR__LDLR__APOE_regulatory_r[HMGCR, LDLR, APOE regulatory regions] -->|debate_co_mention| PGC1A__SIRT1__FOXO3__MITOCHOND
HTT__DMPK__repeat_containing_t[HTT, DMPK, repeat-containing transcripts] -->|debate_co_mention| PGC1A__SIRT1__FOXO3__MITOCHOND
NURR1__PITX3__neuronal_identit[NURR1, PITX3, neuronal identity transcription factors] -->|debate_co_mention| PGC1A__SIRT1__FOXO3__MITOCHOND
Cell_type_specific_essential_g[Cell-type-specific essential genes] -->|co_associated_with| PGC1A__SIRT1__FOXO3__MITOCHOND| Target | Relation | Type | Str |
|---|---|---|---|
| RNA | debate_co_mention | gene | 0.45 |
| RANK | debate_co_mention | gene | 0.45 |
| SIRT1 | debate_co_mention | gene | 0.45 |
| neurodegeneration | associated_with | disease | 0.40 |
| CRISPR | co_associated_with | gene | 0.30 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-827a821b | targets | hypothesis | 0.50 |
| Disease-causing mutations with integrated reporters | debate_co_mention | gene | 0.45 |
| HMGCR, LDLR, APOE regulatory regions | debate_co_mention | gene | 0.45 |
| HTT, DMPK, repeat-containing transcripts | debate_co_mention | gene | 0.45 |
| NURR1, PITX3, neuronal identity transcription factors | debate_co_mention | gene | 0.45 |
| Cell-type-specific essential genes | co_associated_with | gene | 0.40 |
| NURR1, PITX3, neuronal identity transcription factors | co_associated_with | gene | 0.40 |
| Disease-causing mutations with integrated reporters | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci | 0.599 | neurodegeneration | CRISPR-based therapeutic approaches for |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.803
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Targeting a Shared Mitophagy Regulator: The SIRT1-FOXO3-DEPP1 Axis Underpins the [PMID:41743852] | Zhang Y, Guo X, Wang Q, Xiao L, Liu Q, G | Research (Washington, D.C.) | 2026 | 0 |
| VDAC2 loss elicits tumour destruction and inflammation for cancer therapy. [PMID:40108474] | Yuan S, Sun R, Shi H, Chapman NM, Hu H, | Nature | 2025 | 0 |
| Sirtuin-3 activates the mitochondrial unfolded protein response and reduces cere [PMID:37705748] | Xiaowei X, Qian X, Dingzhou Z | International journal of biolo | 2023 | 0 |
| Energy stress modulation of AMPK/FoxO3 signaling inhibits mitochondria-associate [PMID:37267686] | Zhong S, Chen W, Wang B, Gao C, Liu X, S | Redox biology | 2023 | 0 |
| Phosphorylated NFS1 weakens oxaliplatin-based chemosensitivity of colorectal can [PMID:35221331] | Lin JF, Hu PS, Wang YY, Tan YT, Yu K, Li | Signal transduction and target | 2022 | 0 |
| LDHA-mediated metabolic reprogramming promoted cardiomyocyte proliferation by al [PMID:36057161] | Chen Y, Wu G, Li M, Hesse M, Ma Y, Chen | Redox biology | 2022 | 0 |
| Magnetic control of tokamak plasmas through deep reinforcement learning. [PMID:35173339] | Degrave J, Felici F, Buchli J, Neunert M | Nature | 2022 | 0 |
| Cardiomyocyte-derived calcitonin regulates atrial fibrosis and AF. [PMID:33199879] | Fernández-Ruiz I | Nature reviews. Cardiology | 2021 | 0 |
| SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center. [PMID:34469734] | Ou P, Stanek A, Huan Z, Roman CAJ, Huan | Cell reports | 2021 | 0 |
| Complete Genome Sequence of Geobacter sp. Strain FeAm09, a Moderately Acidophili [PMID:33446582] | Yadav P, Antony-Babu S, Hayes E, Healy O | Microbiology resource announce | 2021 | 0 |
| Multifaceted targeting of neurodegeneration with bioactive molecules of saffron [PMID:32470790] | ["Krishnaswamy V", "Alugoju P", "Periyas | Medical hypotheses | 2020 | 0 |
| Activation of the ATF2/CREB-PGC-1α pathway by metformin leads to dopaminergic ne [PMID:28611284] | ["Kang H", "Khang R", "Ham S", "Jeong G" | Oncotarget | 2017 | 0 |
| NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage. [PMID:25798616] | ["Xiong W", "MacColl Garfinkel A", "Li Y | The Journal of clinical invest | 2015 | 0 |
| Functional genomic analysis of frataxin deficiency reveals tissue-specific alter [PMID:19376812] | ["Coppola G", "Marmolino D", "Lu D", "Wa | Human molecular genetics | 2009 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning PGC1A, SIRT1, FOXO3, MITOCHONDRIAL BIOGENESIS GENES in their description or question text
No additional research found