Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NURR1, PITX3, NEURONAL IDENTITY TRANSCRIPTION FACTORS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | NURR1, PITX3, NEURONAL IDENTITY TRANSCRIPTION FACTORS |
graph TD
NURR1__PITX3__NEURONAL_IDENTIT[NURR1, PITX3, NEURONAL IDENTITY TRANSCRIPTION FACTORS]
NURR1__PITX3__NEURONAL_IDENTIT -->|debate_co_mention| PGC1A__SIRT1__FOXO3__mitochond[PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes]
NURR1__PITX3__NEURONAL_IDENTIT -->|debate_co_mention| RANK[RANK]
NURR1__PITX3__NEURONAL_IDENTIT -->|debate_co_mention| SIRT1[SIRT1]
NURR1__PITX3__NEURONAL_IDENTIT -->|debate_co_mention| RNA[RNA]
NURR1__PITX3__NEURONAL_IDENTIT -->|implicated in| neurodegeneration[neurodegeneration]
NURR1__PITX3__NEURONAL_IDENTIT -->|co_associated_with| CRISPR[CRISPR]
h_9d22b570[h-9d22b570] -->|targets| NURR1__PITX3__NEURONAL_IDENTIT
Cell_type_specific_essential_g[Cell-type-specific essential genes] -->|debate_co_mention| NURR1__PITX3__NEURONAL_IDENTIT
Disease_causing_mutations_with[Disease-causing mutations with integrated reporters] -->|debate_co_mention| NURR1__PITX3__NEURONAL_IDENTIT
HMGCR__LDLR__APOE_regulatory_r[HMGCR, LDLR, APOE regulatory regions] -->|debate_co_mention| NURR1__PITX3__NEURONAL_IDENTIT
HTT__DMPK__repeat_containing_t[HTT, DMPK, repeat-containing transcripts] -->|debate_co_mention| NURR1__PITX3__NEURONAL_IDENTIT| Target | Relation | Type | Str |
|---|---|---|---|
| RNA | debate_co_mention | gene | 0.45 |
| PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes | debate_co_mention | gene | 0.45 |
| RANK | debate_co_mention | gene | 0.45 |
| SIRT1 | debate_co_mention | gene | 0.45 |
| neurodegeneration | associated_with | disease | 0.40 |
| PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes | co_associated_with | gene | 0.40 |
| CRISPR | co_associated_with | gene | 0.30 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-9d22b570 | targets | hypothesis | 0.50 |
| Cell-type-specific essential genes | debate_co_mention | gene | 0.45 |
| Disease-causing mutations with integrated reporters | debate_co_mention | gene | 0.45 |
| HMGCR, LDLR, APOE regulatory regions | debate_co_mention | gene | 0.45 |
| HTT, DMPK, repeat-containing transcripts | debate_co_mention | gene | 0.45 |
| Cell-type-specific essential genes | co_associated_with | gene | 0.40 |
| Disease-causing mutations with integrated reporters | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Programmable Neuronal Circuit Repair via Epigenetic CRISPR | 0.596 | neurodegeneration | CRISPR-based therapeutic approaches for |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.803
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Canagliflozin attenuates neurodegeneration and ameliorates dyskinesia through ta [PMID:39700958] | ["Abdelaziz A", "Rasheed N", "Zaki H", " | International immunopharmacolo | 2025 | 0 |
| Nurr1 modulators - a patent review (2019-present). [PMID:40481732] | ["Egner M", "Merk D"] | Expert opinion on therapeutic | 2025 | 0 |
| The role of Nurr1-miR-30e-5p-NLRP3 axis in inflammation-mediated neurodegenerati [PMID:37990334] | ["Li T", "Tan X", "Tian L", "Jia C", "Ch | Journal of neuroinflammation | 2023 | 0 |
| Medicinal Chemistry and Chemical Biology of Nurr1 Modulators: An Emerging Strate [PMID:35797147] | ["Willems S", "Merk D"] | Journal of medicinal chemistry | 2022 | 0 |
| Magnetic control of tokamak plasmas through deep reinforcement learning. [PMID:35173339] | Degrave J, Felici F, Buchli J, Neunert M | Nature | 2022 | 0 |
| Cardiomyocyte-derived calcitonin regulates atrial fibrosis and AF. [PMID:33199879] | Fernández-Ruiz I | Nature reviews. Cardiology | 2021 | 0 |
| SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center. [PMID:34469734] | Ou P, Stanek A, Huan Z, Roman CAJ, Huan | Cell reports | 2021 | 0 |
| Functional characterization of 84 PALB2 variants of uncertain significance. [PMID:31636395] | Wiltshire T, Ducy M, Foo TK, Hu C, Lee K | Genetics in medicine : officia | 2020 | 0 |
| A Case-Control Study of Body Composition, Prevalence, and Curve Severity of the [PMID:29050712] | Zheng Y, Dang Y, Yang Y, Sun N, Wang T, | Spine deformity | 2017 | 0 |
| Pitx3 and En1 determine the size and molecular programming of the dopaminergic n [PMID:28800615] | Kouwenhoven WM, von Oerthel L, Smidt MP | PloS one | 2017 | 0 |
| Computational correction of copy number effect improves specificity of CRISPR-Ca [PMID:29083409] | Meyers RM, Bryan JG, McFarland JM, Weir | Nature genetics | 2017 | 0 |
| Contra-directional Coupling of Nur77 and Nurr1 in Neurodegeneration: A Novel Mec [PMID:26497037] | ["Wei X", "Gao H", "Zou J", "Liu X", "Ch | Molecular neurobiology | 2016 | 0 |
| Transcriptional control of dopamine neuron development. [PMID:12846973] | Wallén A, Perlmann T | Annals of the New York Academy | 2003 | 0 |
| Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midb [PMID:14622207] | Smits SM, Ponnio T, Conneely OM, Burbach | The European journal of neuros | 2003 | 0 |
| Midbrain dopaminergic neurons: determination of their developmental fate by tran [PMID:12846972] | Simon HH, Bhatt L, Gherbassi D, Sgadó P, | Annals of the New York Academy | 2003 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning NURR1, PITX3, NEURONAL IDENTITY TRANSCRIPTION FACTORS in their description or question text
No additional research found