Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HMGCR, LDLR, APOE regulatory regions: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:HMGCR, LDLR, APOE REGULATORY REGIONS | data_in | dataset_row | 0.00 |
| HTT, DMPK, repeat-containing transcripts | debate_co_mention | gene | 0.45 |
| NURR1, PITX3, neuronal identity transcription factors | debate_co_mention | gene | 0.45 |
| PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes | debate_co_mention | gene | 0.45 |
| RANK | debate_co_mention | gene | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:HMGCR, LDLR, APOE REGULATORY REGIONS | data_in | dataset_row | 0.00 |
| BDNF | debate_co_mention | gene | 0.45 |
| BDNF, CREB1, synaptic plasticity genes | debate_co_mention | gene | 0.45 |
| Cell-type-specific essential genes | debate_co_mention | gene | 0.45 |
| Disease-causing mutations with integrated reporters | debate_co_mention | gene | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Cholesterol-CRISPR Convergence Therapy for Neurodegeneration | 0.622 | neurodegeneration | CRISPR-based therapeutic approaches for |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| HMGCR genetic variability in Parkinson's disease in a Spanish cohort: associatio [PMID:41037108] | Díaz-Belloso R, Martín-Bornez M, Macías- | Journal of neurology | 2025 | 0 |
| 25-Hydroxycholesterol attenuates tumor necrosis factor alpha-induced blood-brain [PMID:39181516] | Loiola RA, Nguyen C, Dib S, Saint-Pol J, | Biochimica et biophysica acta. | 2024 | 0 |
| Cholinergic neurodegeneration and cholesterol metabolism dysregulation by consti [PMID:37900943] | ["Comaposada-Bar\u00f3 R", "Benito-Mart\ | Frontiers in molecular neurosc | 2023 | 0 |
| Magnetic control of tokamak plasmas through deep reinforcement learning. [PMID:35173339] | Degrave J, Felici F, Buchli J, Neunert M | Nature | 2022 | 0 |
| Cardiomyocyte-derived calcitonin regulates atrial fibrosis and AF. [PMID:33199879] | Fernández-Ruiz I | Nature reviews. Cardiology | 2021 | 0 |
| SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center. [PMID:34469734] | Ou P, Stanek A, Huan Z, Roman CAJ, Huan | Cell reports | 2021 | 0 |
| Quinovic Acid Impedes Cholesterol Dyshomeostasis, Oxidative Stress, and Neurodeg [PMID:33274012] | ["Saeed K", "Shah S", "Ullah R", "Alam S | Oxidative medicine and cellula | 2020 | 0 |
| The beneficial effects of HMG-CoA reductase inhibitors in the processes of neuro [PMID:28578514] | ["Saeedi Saravi S", "Saeedi Saravi S", " | Metabolic brain disease | 2017 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HMGCR, LDLR, APOE regulatory regions in their description or question text
No additional research found