gene

CTSZ

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CTSZ: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections

0Hypotheses

0Analyses

11Outgoing

5Incoming

0Experiments

0Debates

Summary

Page for CTSZ Gene - Cathepsin Z

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🧬 Gene Info

Gene Symbol	CTSZ
Full Name	Cathepsin Z
Aliases	Page for CTSZ Gene
Chromosome	20q13.12
Protein Type	Protease
Function	, also known as Cathepsin X, is a unique lysosomal cysteine protease that possesses both endopeptidase and carboxypeptidase activities[@bhling2004]
Primary Expression	AD brain and localizes to amyloid plaques[@wang2012] 2
Pathways	Autophagy, Immune Response, Mitophagy, lysosomal function
UniProt ID	[O60840](https://www.uniprot.org/uniprot/O60840)
Ensembl ID	ENSG00000021574
OMIM	602088
GeneCards	CTSZ
Human Protein Atlas	CTSZ
Lysosomal Protein Degradation	Central role in cellular protein turnover
Immune Regulation	Modulates T-cell function and macrophage activity
Associated Diseases	neurodegeneration
Interactions	ALZHEIMER, AMYLOID, Amyloid Beta, AUTOPHAGY, Aβ, CATHEPSINS
KG Connections	16 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CTSZ Gene - Cathepsin Z

gene · 652 words

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Pathway Diagram

flowchart TD
    N0["CTSZ"]
    N1["lysosomal function"]
    N0 -->|"regulates"| N1
    N2["Urolithin A"]
    N2 -->|"regulates"| N0
    N3["Alzheimer"]
    N0 -->|"activates"| N3
    N4["Als"]
    N0 -->|"activates"| N4
    N5["AMYLOID"]
    N0 -->|"activates"| N5
    N6["AUTOPHAGY"]
    N0 -->|"activates"| N6
    N7["Autophagy"]
    N0 -->|"activates"| N7
    N8["Mitophagy"]
    N0 -->|"activates"| N8
    N9["Immune Response"]
    N0 -->|"activates"| N9
    N10["Abeta"]
    N0 -->|"activates"| N10
    N11["Amyloid Beta"]
    N0 -->|"activates"| N11
    N12["Cathepsin"]
    N0 -->|"regulates"| N12
    N13["ALZHEIMER"]
    N13 -->|"activates"| N0
    N14["CATHEPSINS"]
    N14 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N3 disease
    class N4 disease
    class N5 gene
    class N6 gene
    class N7 pathway
    class N8 pathway
    class N9 pathway
    class N10 protein
    class N11 protein
    class N12 protein
    class N13 gene
    class N14 gene

Outgoing (11)

Target	Relation	Type	Str
lysosomal function	regulates	process	0.70
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
AMYLOID	activates	gene	0.60
Immune Response	activates	pathway	0.60
Aβ	activates	protein	0.60
Amyloid Beta	activates	protein	0.60
Cathepsin	regulates	protein	0.60
Mitophagy	activates	pathway	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60

Incoming (5)

Source	Relation	Type	Str
Urolithin A	regulates	drug	0.70
CATHEPSINS	activates	gene	0.60
TAU	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
MITOPHAGY	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CTSZ in their description or question text

No additional research found