gene

CNTNAP4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CNTNAP4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections

0Hypotheses

0Analyses

48Outgoing

15Incoming

0Experiments

0Debates

Summary

CNTNAP4 is a gene implicated in neurodegeneration research. Key relationships include: causes, associated with, activates. Associated with Autism, PD, Parkinson. Connected to 25 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	Contactin-Associated Protein 4
Chromosome	16q23.3
Protein Type	Neurexin family cell adhesion molecule
Function	is a member of the neurexin family of transmembrane adhesion proteins.
Primary Expression	Brain (cortex, hippocampus, cerebellum), spinal cord
Pathways	Complement, SNCA Pathology
UniProt ID	Q9C0A0
NCBI Gene ID	12925
Ensembl ID	ENSG00000171804
OMIM	610610
Contactin domain	Enables homophilic and heterophilic interactions with other CNTNAP proteins
Neurexin repeat domains	Support protein-protein interactions at the synaptic cleft
FFC domain	Found in fibrinogen-related proteins, involved in carbohydrate binding
PDZ-binding motif	Interacts with PDZ domain-containing scaffolding proteins
Proline-rich region	Potential protein interaction site
Associated Diseases	Autism, Parkinson, PD
Interactions	C1Q, MICROGLIA, NEURON, Rb
KG Connections	63 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CNTNAP4 — AlphaFold Q9C0A0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CNTNAP4 Gene

gene · 1548 words

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Pathway Diagram

graph TD
    CNTNAP4["CNTNAP4"]
    Autism{"Autism"}
    CNTNAP4 -->|"associated with"| Autism
    Parkinson{"Parkinson"}
    CNTNAP4 -->|"activates"| Parkinson
    CNTNAP4 -->|"associated with"| Parkinson
    CNTNAP4 -->|"causes"| Parkinson
    ALPHA_SYNUCLEIN["ALPHA_SYNUCLEIN"]
    CNTNAP4 -->|"regulates"| ALPHA_SYNUCLEIN
    Complement(["Complement"])
    CNTNAP4 -->|"activates"| Complement
    CNTNAP4 -->|"associated with"| Complement
    CYTOKINES["CYTOKINES"]
    CNTNAP4 -->|"causes"| CYTOKINES
    CNTNAP4 -->|"causes"| Complement
    PD{"PD"}
    CNTNAP4 -->|"associated with"| PD
    Microglia["Microglia"]
    CNTNAP4 -->|"expressed in"| Microglia
    Astrocyte["Astrocyte"]
    CNTNAP4 -->|"expressed in"| Astrocyte
    C1Q["C1Q"]
    C1Q -->|"activates"| CNTNAP4
    C1Q -->|"associated with"| CNTNAP4
    COMPLEMENT["COMPLEMENT"]
    COMPLEMENT -->|"causes"| CNTNAP4
    ASTROCYTES["ASTROCYTES"]
    ASTROCYTES -->|"causes"| CNTNAP4
    C1Q -->|"causes"| CNTNAP4
    NEURON["NEURON"]
    NEURON -->|"activates"| CNTNAP4
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"protects against"| CNTNAP4
    ASTROCYTE["ASTROCYTE"]
    ASTROCYTE -->|"associated with"| CNTNAP4
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"causes"| CNTNAP4
    PARKINSON["PARKINSON"]
    PARKINSON -->|"causes"| CNTNAP4
    AND["AND"]
    AND -->|"regulates"| CNTNAP4
    CYTOKINES -->|"causes"| CNTNAP4
    style CNTNAP4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (48)

Target	Relation	Type	Str
SNCA Pathology	regulates	process	0.90
α-synuclein pathology	exacerbates	process	0.80
nigrostriatal DA neuron degeneration	exacerbates	process	0.80
ASTROCYTE	interacts_with	cell_type	0.80
Autism	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Parkinson	causes	disease	0.65
Parkinson	associated_with	disease	0.65
ALPHA_SYNUCLEIN	regulates	protein	0.64
C1Q	causes	gene	0.60
Complement	activates	pathway	0.60
PARKINSON	causes	gene	0.60
AND	regulates	gene	0.60
ASTROCYTES	causes	gene	0.60
NEURON	activates	gene	0.60
PARKINSON'S DISEASE	causes	gene	0.60
MICROGLIA	protects_against	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
Dopaminergic	causes	cell_type	0.60
Microglia	therapeutic_target	cell_type	0.60
Neuron	activates	cell_type	0.60
ASTROCYTE	associated_with	gene	0.60
COMPLEMENT	causes	gene	0.60
Astrocyte	associated_with	cell_type	0.60
CYTOKINES	causes	gene	0.60
Complement	causes	pathway	0.60
CYTOKINES	contributes_to	gene	0.60
ASTROCYTES	contributes_to	gene	0.60
COMPLEMENT	contributes_to	gene	0.60
PARKINSON	contributes_to	gene	0.60
Dopaminergic	contributes_to	cell_type	0.60
Α-Synuclein	therapeutic_target	protein	0.60
Cytokine	contributes_to	protein	0.60
Microglia	inhibits	cell_type	0.60
Rb	activates	protein	0.60
Complement	associated_with	pathway	0.60
PD	associated_with	disease	0.56
Neuron	expressed_in	cell_type	0.55
Microglia	expressed_in	cell_type	0.55
Astrocyte	expressed_in	cell_type	0.55
SYNUCLEIN	decreases_risk	concept	0.50
α-SYNUCLEIN	decreases_risk	concept	0.50
SYNUCLEIN	activates	concept	0.50
α-SYNUCLEIN	activates	concept	0.50
SYNUCLEIN	associated_with	concept	0.50
α-SYNUCLEIN	regulates	concept	0.50
SYNUCLEIN	regulates	concept	0.50
α-SYNUCLEIN	associated_with	concept	0.50

Incoming (15)

Source	Relation	Type	Str
COMPLEMENT	causes	gene	0.60
ASTROCYTES	causes	gene	0.60
NEURON	activates	gene	0.60
MICROGLIA	protects_against	gene	0.60
ASTROCYTE	associated_with	gene	0.60
PARKINSON'S DISEASE	causes	gene	0.60
PARKINSON	causes	gene	0.60
AUTISM	associated_with	entity	0.60
C1Q	associated_with	gene	0.60
MICROGLIA	inhibits	gene	0.60
C1Q	activates	gene	0.60
CYTOKINES	causes	gene	0.60
C1Q	causes	gene	0.60
microglia	associated_with	cell_type	0.50
microglia	decreases_risk	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CNTNAP4 in their description or question text

No additional research found