gene

CHN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

38Connections

0Hypotheses

0Analyses

24Outgoing

14Incoming

0Experiments

0Debates

Summary

Alpha-1-chimaerin GTPase-activating protein, roles in Charcot-Marie-Tooth disease, synaptic development, and neurodegeneration

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🧬 Gene Info

Gene Symbol	CHN1
Full Name	Chimerin 1
Chromosome	2q31.1
Protein Family	Rho GTPase-activating proteins (RhoGAPs)
Function	Alpha-1-chimaerin is expressed predominantly in the nervous system and functions as a critical regulator of Rho GTPase signaling.
Primary Expression	Neuron-specific, high in brain and peripheral nervous system
UniProt ID	P15884
NCBI Gene ID	1123
GeneCards	CHN1
Human Protein Atlas	CHN1
Actin cytoskeleton dynamics	Rac1 controls the formation of actin-rich structures including lamellipodia, filopodia, and dendritic spines
Cell adhesion	Rac1 regulates integrin-mediated adhesion to the extracellular matrix
Cytokinesis	Rac1 plays roles in cell division during development
Dendritic morphogenesis	CHN1 regulates Rac1 activity to control dendritic arborization and spine formation[@rac2007]
Axon guidance	Rac1 signaling influences growth cone dynamics and pathfinding during axon extension
Associated Diseases	Alzheimer, Amyotrophic Lateral Sclerosis, disease, neurodegeneration, Neurodegenerative Diseases, Parkinson
KG Connections	38 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CHN1 — AlphaFold P15884 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CHN1 — Chimerin 1

gene · 1631 words

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Pathway Diagram

graph TD
    CHN1["CHN1"]
    Alzheimer["Alzheimer"]
    CHN1 -->|"therapeutic target"| Alzheimer
    Als["Als"]
    CHN1 -->|"therapeutic target"| Als
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CHN1 -->|"therapeutic target"| Amyotrophic_Lateral_Sclerosis
    Parkinson["Parkinson"]
    CHN1 -->|"therapeutic target"| Parkinson
    Parkinson["Parkinson"]
    CHN1 -->|"associated with"| Parkinson
    Alzheimer["Alzheimer"]
    CHN1 -->|"associated with"| Alzheimer
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    CHN1 -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    ALZHEIMER["ALZHEIMER"]
    CHN1 -->|"therapeutic target"| ALZHEIMER
    ALS["ALS"]
    CHN1 -->|"therapeutic target"| ALS
    MDH1["MDH1"]
    CHN1 -->|"associated with"| MDH1
    RTN1["RTN1"]
    CHN1 -->|"associated with"| RTN1
    SNAP25["SNAP25"]
    CHN1 -->|"associated with"| SNAP25
    PARKINSON["PARKINSON"]
    CHN1 -->|"therapeutic target"| PARKINSON
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    CHN1 -->|"associated with"| ALZHEIMER_S_DISEASE
    MICRORNAS["MICRORNAS"]
    CHN1 -->|"associated with"| MICRORNAS
    ALS["ALS"]
    CHN1 -->|"associated with"| ALS
    PI3K["PI3K"]
    CHN1 -->|"associated with"| PI3K
    NEURODEGENERATIVE_DISORDERS["NEURODEGENERATIVE DISORDERS"]
    CHN1 -->|"associated with"| NEURODEGENERATIVE_DISORDERS
    MICRORNAS["MICRORNAS"]
    MICRORNAS -->|"therapeutic target"| CHN1
    GENES["GENES"]
    GENES -->|"associated with"| CHN1
    AKT["AKT"]
    AKT -->|"associated with"| CHN1
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    AMYOTROPHIC_LATERAL_SCLEROSIS -->|"associated with"| CHN1
    PARKINSON["PARKINSON"]
    PARKINSON -->|"associated with"| CHN1
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated with"| CHN1
    MDH1["MDH1"]
    MDH1 -->|"associated with"| CHN1
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"associated with"| CHN1
    RTN1["RTN1"]
    RTN1 -->|"associated with"| CHN1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"associated with"| CHN1
    AND["AND"]
    AND -->|"associated with"| CHN1
    neurodegeneration["neurodegeneration"]
    CHN1 -->|"implicated in"| neurodegeneration

Outgoing (24)

Target	Relation	Type	Str
Parkinson	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
ALS	therapeutic_target	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
PI3K	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60
ALS	associated_with	gene	0.60
NEURODEGENERATIVE DISORDERS	associated_with	gene	0.60
Pi3K	therapeutic_target	protein	0.60
RTN1	associated_with	gene	0.60
SNAP25	associated_with	gene	0.60
Akt	therapeutic_target	protein	0.60
MDH1	associated_with	gene	0.60
neurodegeneration	associated_with	disease	0.60
Neurodegenerative Diseases	associated_with	disease	0.50
disease	associated_with	disease	0.50
SNAP25	co_mentioned	gene	0.40

Incoming (14)

Source	Relation	Type	Str
AKT	associated_with	gene	0.60
MDH1	associated_with	gene	0.60
RTN1	associated_with	gene	0.60
SNAP25	associated_with	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
ALS	therapeutic_target	gene	0.60
MICRORNAS	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
AND	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHN1 in their description or question text

No additional research found