| Gene Symbol | USP30 |
| Full Name | Ubiquitin Specific Peptidase 30 |
| Chromosome | 12p11.23 |
| Protein Type | Enzyme |
| Function | is a critical deubiquitinating enzyme (DUB) uniquely localized to the outer mitochondrial membrane (OMM), where it serves as a key regulator of mitochondrial quality control through mitophagy [@bin... |
| Subcellular Localization | the outer mitochondrial membrane (OMM), where it serves as a key regulator of mitochondrial quality control through mito |
| Molecular Weight | 58 kDa |
| Amino Acids | 517 aa |
| Pathways | Autophagy, Mitophagy |
| Ensembl ID | ENSG00000196811 |
| GeneCards | USP30 |
| Human Protein Atlas | USP30 |
| N-terminus | Cytoplasmic (facing the cytosol) |
| C-terminus | Intermembrane space-facing |
| Substrate specificity | Prefers K6- and K63-linked ubiquitin chains |
| Associated Diseases | Als, Cardiac, Ms |
| Interactions | AND, ATF3, AUTOPHAGY, COX4I1, CYTOCHROME C, FOXO3 |
| SciDEX Hypotheses | Mitophagy Induction as Neuroprotective Strategy in |
| KG Connections | 147 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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