concept

UBE3C

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBE3C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

0Analyses

29Outgoing

11Incoming

0Experiments

0Debates

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💡 Concept Info

Name	UBE3C
Key Genes/Proteins	AND, App, ATG4B, AUTOPHAGY, CGAS, GAIN
Related Diseases	Als, ALS, CGAS K27 ubiquitination
Related Pathways	autophagy pathway

Pathway Diagram

graph TD
    UBE3C["UBE3C"]
    UBE3C -->|"interacts"| ATG4B["ATG4B"]
    UBE3C -->|"catalyzes_ubiquitination_of"| CGAS["CGAS"]
    UBE3C -->|"causes"| CGAS_K27_ubiquitination["CGAS K27 ubiquitination"]
    UBE3C -->|"inhibits"| Autophagy["Autophagy"]
    UBE3C -->|"regulates"| Als["Als"]
    UBE3C -->|"regulates"| ALS["ALS"]
    UL21["UL21"] -->|"activates"| UBE3C
    ATG4B -->|"inhibits"| UBE3C
    LC3["LC3"] -->|"inhibits"| UBE3C
    AUTOPHAGY["AUTOPHAGY"] -->|"inhibits"| UBE3C
    UBIQUITIN["UBIQUITIN"] -->|"inhibits"| UBE3C
    AND["AND"] -->|"inhibits"| UBE3C

Outgoing (29)

Target	Relation	Type	Str
ATG4B	interacts_with	protein	0.95
CGAS	catalyzes_ubiquitination_of	protein	0.93
ATG4B	phosphorylates	protein	0.90
CGAS	modifies	protein	0.90
CGAS K27 ubiquitination	causes	phenotype	0.90
ATG4B	associated_with	protein	0.90
Autophagy	inhibits	process	0.88
Als	stabilizes	disease	0.65
Als	degrades	disease	0.65
Als	regulates	disease	0.65
ALS	regulates	disease	0.65
UBIQUITIN	inhibits	gene	0.60
MAP1LC3	inhibits	gene	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
AUTOPHAGY	inhibits	gene	0.60
autophagy pathway	participates_in	pathway	0.60
ATG4B	inhibits	gene	0.60
App	inhibits	protein	0.60
GAIN	stabilizes	gene	0.60
NRF1	stabilizes	gene	0.60
AUTOPHAGY	stabilizes	gene	0.60
Autophagy	stabilizes	pathway	0.60
Ubiquitin-Proteasome	stabilizes	pathway	0.60
LC3	inhibits	gene	0.60
ATG4B	degrades	gene	0.60
UBIQUITIN	degrades	gene	0.60
AUTOPHAGY	degrades	gene	0.60
Autophagy	degrades	pathway	0.60
AND	inhibits	gene	0.60

Incoming (11)

Source	Relation	Type	Str
UL21	activates	protein	0.80
UL21	interacts_with	protein	0.80
ATG4B	degrades	gene	0.60
ATG4B	associated_with	gene	0.60
ATG4B	causes	gene	0.60
ATG4B	interacts_with	gene	0.60
ATG4B	regulates	gene	0.60
ATG4B	inhibits	gene	0.60
LC3	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UBE3C in their description or question text

No additional research found