concept

RLN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RLN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

31Connections

0Hypotheses

0Analyses

26Outgoing

5Incoming

0Experiments

0Debates

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💡 Concept Info

Name	RLN
Key Genes/Proteins	AKT1, APP, BDNF, GDNF
Related Diseases	Alzheimer's Disease, Alzheimer'S Disease, Arthritis, Atherosclerosis, Autism
Related Pathways	Jak/Stat Pathway

Pathway Diagram

graph TD
    RLN[RLN]
    RLN -->|regulates| Neuronal_Migration[Neuronal Migration]
    RLN -->|regulates| Dendritic_Growth[Dendritic Growth]
    RLN -->|regulates| Dendritic_Spine_Formation[Dendritic Spine Formation]
    RLN -->|regulates| Synaptogenesis[Synaptogenesis]
    RLN -->|regulates| Synaptic_Function[Synaptic Function]
    RLN -->|regulates| Synaptic_Plasticity[Synaptic Plasticity]
    RLN -->|binds| VLDLR[VLDLR]
    RLN -->|binds| LRP8[LRP8]
    RLN -->|contributes to| Platelet_Adhesion[Platelet Adhesion]
    RLN -->|contributes to| Coagulation[Coagulation]
    VLDLR -->|binds| RLN
    APP[APP] -->|modulates| RLN
    benchmark_ot_ad_answer_key_RLN[benchmark_ot_ad_answer_key:RLN] -->|data_in| RLN

Outgoing (26)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:RLN	data_in	dataset_row	0.00
Neuronal Migration	regulates	process	0.95
Dendritic Growth	regulates	process	0.95
Dendritic Spine Formation	regulates	process	0.95
Synaptogenesis	regulates	process	0.95
Synaptic Function	regulates	process	0.95
Synaptic Plasticity	regulates	process	0.95
VLDLR	binds	receptor	0.90
LRP8	binds	protein	0.90
Coagulation	contributes_to	process	0.85
Jak/Stat Pathway	activates	pathway	0.85
NMDA receptor	activates	protein	0.85
Platelet Adhesion	contributes_to	process	0.85
PIK3CA	phosphorylates	gene	0.85
AKT1	phosphorylates	gene	0.85
Lissencephaly	associated_with	disease	0.85
Autism	associated_with	disease	0.85
Schizophrenia	associated_with	disease	0.85
Alzheimer's Disease	associated_with	disease	0.85
Epilepsy	associated_with	disease	0.85
NFKB	phosphorylates	gene	0.85
Leukocyte Permeability	contributes_to	process	0.80
Arthritis	associated_with	disease	0.75
Alzheimer'S Disease	associated_with	disease	0.75
Atherosclerosis	associated_with	disease	0.75
Multiple Sclerosis	associated_with	disease	0.75

Incoming (5)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:RLN	data_in	dataset_row	0.00
VLDLR	binds	receptor	0.90
APP	modulates	gene	0.75
BDNF	associated_with	gene	0.60
GDNF	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RLN in their description or question text

No additional research found