protein

REV

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about REV: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

24Connections
30Hypotheses
0Analyses
10Outgoing
14Incoming
2Experiments
0Debates

Summary

REV-ERBβ Protein

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🔬 Protein Info
Gene SymbolREV
Protein FamilyNuclear receptor family, REV-ERB subfamily
Subcellular Localizationsignal - **Ligand-binding domain (LBD)**: Binds heme as an endogenous ligand; co
Molecular Weight~51 kDa
Pathwayscircadian regulation
UniProt IDQ9UGL9
GeneCardsREV
Human Protein AtlasREV
Associated DiseasesALS
Known Drugs/Compoundslithium
InteractionsBMAL1, CLOCK, HDAC3
KG Connections24 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: REV — AlphaFold Q9UGL9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

REV-ERBα Protein

protein · 1100 words

REV-ERBβ Protein

protein · 869 words

SYNAPTOBREVIN-2 Protein (VAMP2)

protein · 814 words

NR1D1 — Nuclear Receptor Subfamily 1 Group D Member 1 (REV-ERBα)

gene · 616 words

Pathway Diagram

graph TD
    REV(["REV"])
    style REV fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    circadian_regulation(["circadian regulation"])
    HDAC3["HDAC3"]
    BMAL1(["BMAL1"])
    CLOCK["CLOCK"]

    REV -->|"participates_in"| circadian_regulation
    HDAC3 -->|"activates"| REV
    BMAL1 -.->|"inhibits"| REV
    CLOCK -.->|"inhibits"| REV
    BMAL1 -->|"activates"| REV

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class circadian_regulation protein
    class HDAC3 gene
    class BMAL1 protein
    class CLOCK gene

Outgoing (10)

TargetRelationTypeStr
circadian regulationparticipates_inpathway0.75
neuronsexpressed_incell_type0.70
stem cellsexpressed_incell_type0.60
oxidative stress responseparticipates_inpathway0.60
T cellsexpressed_incell_type0.60

Incoming (14)

SourceRelationTypeStr
BMAL1regulatesgene0.70
PER1regulatesgene0.70
lithiumtargetsdrug0.60
BMAL1associated_withgene0.60
PER1associated_withgene0.60

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Closed-loop optogenetic targeting PV interneurons to restore 0.959 Alzheimer's disease Circuit-level neural dynamics in neurode
Gut Microbiome Remodeling to Prevent Systemic NLRP3 Priming 0.924 neurodegeneration What are the mechanisms by which gut mic
SIRT1-Mediated Reversal of TREM2-Dependent Microglial Senesc 0.893 neurodegeneration Gene expression changes in aging mouse b
Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Pa 0.887 - Do β-amyloid plaques and neurofibrillary
Closed-loop focused ultrasound targeting EC-II PV interneuro 0.863 Alzheimer's disease Circuit-level neural dynamics in neurode
miR-155/Interferon-gamma Feedback Loop as a Reversible Molec 0.843 neurodegeneration How do different microglial subtypes (DA
Sequential Iron Chelation (Deferoxamine) and GPX4 Restoratio 0.838 neurodegeneration View
Microglial Senescence Prevention via TREM2/SASP Axis 0.837 neurodegeneration View
SLC7A11 System Activation Restores Cystine Uptake and GSH Sy 0.812 neurodegeneration View
Targeting the Mechanistic Link Between AQP4 Dysfunction and 0.803 neurodegeneration View
Closed-loop transcranial focused ultrasound targeting CA1 PV 0.797 Alzheimer's disease Circuit-level neural dynamics in neurode
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam 0.789 neurodegeneration What are the mechanisms by which gut mic
NLRP3 Inhibition (H7): Downstream Inflammatory Reversal 0.780 neurodegeneration Does restoring neuronal AMPK activity re
HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA 0.766 neurodegeneration What molecular mechanisms explain how ap
VPS35 retromer activation prevents endosomal tau templating 0.740 neurodegeneration Which tau propagation mechanism predomin
Ultra-Low Physiological Replacement Dosing for Long-Term Pre 0.735 - What is the optimal dosage and timing of
SNCA Oligomer Binding to LAMP2A Cytosolic Tail Prevents Tors 0.733 neurodegeneration -
Ubiquitin-Mediated Liquid-to-Solid Transition Prevention 0.730 neurodegeneration How does TRIM21-mediated K63 ubiquitinat
C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD 0.720 neurodegeneration Test Hypothesis Fixtures
Metabolic Reprogramming to Reverse Senescence 0.720 - Senescent cell clearance as neurodegener
EZH2-Mediated H3K27me3 Spreading in Senescent ALS Microglia 0.714 ALS What are the mechanisms by which microgl
Liquid-to-Solid Transition Pathology Reveals Granule Weak Po 0.712 neurodegeneration What determines the specificity of RNA-p
Closed-loop transcranial focused ultrasound targeting EC-II 0.712 Alzheimer's disease Circuit-level neural dynamics in neurode
H4: Senomorphic Compounds Preserve Astrocyte Function While 0.710 neurodegeneration Do APOE4-driven senescent astrocytes cau
Conformational-Selective Blocking of Tau Uptake Reveals Ther 0.710 neurodegeneration What is the therapeutic window between t
TRIM21 as a 'Phase Separation Thermostat' via Catalytic Reve 0.700 neurodegeneration How does TRIM21-mediated K63 ubiquitinat
Ataxin-2 Polyglutamine Expansions Hijack G3BP1 to Form Toxic 0.700 neurodegeneration How do disease-associated mutations in G
Cross-Seeding Prevention Strategy 0.689 neurodegeneration RNA binding protein dysregulation across
Neuronal AMPK Restoration (H1): Direct Reversibility Test 0.680 neurodegeneration Does restoring neuronal AMPK activity re
CYP46A1-Mediated Cholesterol Reduction Prevents eIF2α-Driven 0.000 neurodegeneration Lipid raft composition changes in synapt

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (2)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
Anti-miR-155 LNA Oligonucleotide Shifts Microglia to Homeostatic State in_vivo neurodegeneration 0.774 0.65 C57BL/6J LPS model (chronic i. proposed $58,000
Sequential DFO + Sulforaphane Prevents Iron-Ferroptosis Cascade in Rat in_vivo post-cardiac-arrest neurodegen 0.768 0.72 Sprague-Dawley rat asphyxial c abandoned $48,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Changes in Circulating Levels of miR-30b During Minipuberty and Puberty in Girls [PMID:40899010] Albrechtsen HM, Saritas G, Winge SB, Mai J Clin Endocrinol Metab 2026 0
Epigenetics in chronic rhinosinusitis. [PMID:41442742] Kumar N, Brar T, Lal D Curr Opin Otolaryngol Head Nec 2026 0
ACSL4-mediated astrocyte ferroptosis augments neuroinflammation and exacerbates [PMID:41776085] Wen H, Zi Y, Liu Z, Bai Y, Lin J et al. Cell Death Differ 2026 0
Extracellular vesicles in type 2 diabetes exhibit elevated miR-155 cargo and Ann [PMID:41786286] Jackson G, Islam H, de Souza Teixeira AA Life Sci 2026 0
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] Mishra R, Gupta JK Curr Alzheimer Res 2026 0
Multimodal MR Imaging Reveals the Mechanisms of Post-Cardiac-Arrest Brain edema: [PMID:41933462] Tan Y, Ye H, Ge Q, Wang P, Liu Z et al. J Magn Reson Imaging 2026 0
Di-2-ethylhexylphthalate-induced miR155-5P promotes placental ferroptosis. [PMID:41937013] Gu X, Sun F, Li Y, Yang S, Li Y Int J Biol Macromol 2026 0
Extracellular Vesicles in Obesity: From Pathophysiological Mediators to Therapeu [PMID:41977323] Pavlović N, Todorović P, Maglica M, Kopi Int J Mol Sci 2026 0
Decoding microRNA-Protein Interaction Networks in Alzheimer's Disease: Molecular [PMID:41918207] Mishra R, Gupta JK Current Alzheimer research 2026 0
Aquaporin 4 knockdown alleviates traumatic brain edema and reduces neuronal axon [PMID:41967652] Fang J, Pan X, Chen J Neurobiol Dis 2026 0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
Enhancing TREM2 expression activates microglia and modestly mitigates tau pathol [PMID:40122810] ["Chen Kai", "Li Fuyao", "Zhang Shuwen", Journal of neuroinflammation 2025 0
Increased Neuronal Expression of the Early Endosomal Adaptor APPL1 Replicates Al [PMID:40514243] Jiang Y, Sachdeva K, Goulbourne CN, Berg The Journal of neuroscience : 2025 0
P-tau217 correlates with neurodegeneration in Alzheimer's disease, and targeting [PMID:38513667] Zhang D, Zhang W, Ming C, Gao X, Yuan H, Neuron 2024 0
The necroptosis cell death pathway drives neurodegeneration in Alzheimer's disea [PMID:38852117] Balusu S, De Strooper B Acta neuropathologica 2024 0
The cornel Iridoid glycoside attenuated brain edema of the cerebral ischemia/rep [PMID:38950636] Wang Z, Xue F, Zhang J Fitoterapia 2024 0
Chemical genetic activation of the cholinergic basal forebrain hippocampal circu [PMID:35418161] Weilin Liu, Jianhong Li, Minguang Yang {'name': "Alzheimer's Research 2022 0
Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease. [PMID:34069890] Burillo J, Marqués P, Jiménez B, Gonzále Cells 2021 0
CD38 in Neurodegeneration and Neuroinflammation. [PMID:32085567] Guerreiro S, Privat AL, Bressac L, Toulo Cells 2020 0
Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] Marogianni C, Sokratous M, Dardiotis E, International journal of molec 2020 0

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning REV in their description or question text

miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Prot

Score: 0.843 · neurodegeneration · 2026-04-16

## Mechanistic Overview miR-155/Interferon-gamma Feedback Loop as a Reversible Molecular Switch for Protective Microglia

Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Pre

Score: 0.838 · neurodegeneration · 2026-04-17

## Mechanistic Overview Sequential Iron Chelation (Deferoxamine) and GPX4 Restoration (Sulforaphane) Prevents the Self-A

Microglial Senescence Prevention via TREM2/SASP Axis

Score: 0.837 · neurodegeneration · 2026-04-17

## Mechanistic Overview Microglial Senescence Prevention via TREM2/SASP Axis starts from the claim that modulating not y

SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent N

Score: 0.812 · neurodegeneration · 2026-04-17

## Mechanistic Overview SLC7A11 System Activation Restores Cystine Uptake and GSH Synthesis to Prevent Neuronal and Endo

Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents

Score: 0.803 · neurodegeneration · 2026-04-17

## Mechanistic Overview Targeting the Mechanistic Link Between AQP4 Dysfunction and Ferroptosis Prevents Both Cytotoxic

Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

Score: 0.797 · Alzheimer's disease · 2026-04-07

## Mechanistic Overview Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with real-time gamma f

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflammatory Priming

Score: 0.789 · neurodegeneration · 2026-04-02

## Mechanistic Overview Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflammatory Priming starts from the claim

NLRP3 Inhibition (H7): Downstream Inflammatory Reversal

Score: 0.780 · neurodegeneration · 2026-04-25

Pharmacological NLRP3 inhibition via MCC950 breaks the lipid-inflammasome feedback loop that perpetuates microglial acti

HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA Prevention

Score: 0.766 · neurodegeneration · 2026-04-15

## Mechanistic Overview HDL/apoE Particle Remodeling as a Therapeutic Switch for CAA Prevention starts from the claim th

VPS35 retromer activation prevents endosomal tau templating across all brain reg

Score: 0.740 · neurodegeneration · 2026-04-21

## Mechanistic Overview VPS35 retromer activation prevents endosomal tau templating across all brain regions and disease

Ultra-Low Physiological Replacement Dosing for Long-Term Prevention

Score: 0.735 · unknown disease · 2026-04-26

Nano-dose melatonin (0.1-0.3mg) produces optimal BACE1 suppression and antioxidant effects without disrupting endogenous

Ubiquitin-Mediated Liquid-to-Solid Transition Prevention

Score: 0.730 · neurodegeneration · 2026-04-21

## **Molecular Mechanism and Rationale** The pathological transition of stress granules from dynamic liquid-like conden

C9orf72 ASO Treatment Reverses TDP-43 Pathology in ALS/FTD

Score: 0.720 · neurodegeneration · 2026-04-26

Antisense oligonucleotides targeting C9orf72 hexanucleotide repeat expansion reduce toxic DPR proteins and RNA foci, res

Metabolic Reprogramming to Reverse Senescence

Score: 0.720 · unknown disease · 2026-04-16

# Metabolic Reprogramming to Reverse Senescence in Neurodegeneration: A Mechanistic Hypothesis ## The Senescence Conund