| Gene Symbol | REV |
| Full Name | ERBα Protein — Nuclear Receptor Subfamily 1 Group D Member 1 |
| Protein Family | Nuclear receptor family, REV-ERB subfamily |
| Subcellular Localization | signal - **Ligand-binding domain (LBD)**: Binds heme as an endogenous ligand; co |
| Molecular Weight | ~51 kDa |
| Pathways | circadian regulation |
| UniProt ID | Q9UGL9 |
| GeneCards | REV |
| Human Protein Atlas | REV |
| N-terminal domain (NTD) | Contains the ligand-independent activation function (AF-1) and contributes to transcriptional repression |
| DNA-binding domain (DBD) | Two C4-type zinc fingers that recognize the Rev-DR2 response element (TGACCCTTTF) in target gene promoters |
| Hinge region | Flexible domain connecting DBD to LBD; contains the nuclear localization signal |
| Ligand-binding domain (LBD) | Binds heme as an endogenous ligand; contains the AF-2 activation function |
| Suprachiasmatic nucleus (SCN) | Coordinates central circadian pacemaking |
| Hippocampus | Involved in memory formation and synaptic plasticity |
| Associated Diseases | ALS |
| Known Drugs/Compounds | lithium |
| Interactions | BMAL1, CLOCK, HDAC3 |
| KG Connections | 24 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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