| Gene Symbol | NR1D2 |
| Aliases | REV-ERBβ |
| Chromosome | 3p24.2. |
| Protein Type | Receptor |
| Function | is a nuclear receptor protein that functions as a transcriptional repressor and plays a critical role in the molecular circadian clock[@partch2014]. |
| Subcellular Localization | ** | Nucleus | |
| Molecular Weight | 51 kDa |
| Amino Acids | 478 aa |
| Ensembl ID | ENSG00000150051 |
| GeneCards | NR1D2 |
| Human Protein Atlas | NR1D2 |
| Hinge region | This flexible linker connects the DBD to the ligand-binding domain and often contains sequences important for protein-protein interactions and nuclear localization. |
| N-terminal domain | Contains a transcriptional activation function (AF-1) that can modulate receptor activity in a cell-type specific manner. |
| BMAL1 repression | NR1D2 represses the transcriptional activity of the BMAL1/CLOCK heterodimer by binding to RREs and recruiting co-repressor complexes |
| Negative feedback loop | NR1D2 expression is driven by BMAL1/CLOCK, and then REV-ERBβ represses BMAL1 expression, forming the nighttime repression arm of the circadian clock |
| Associated Diseases | Parkinson's disease, Alzheimer's disease |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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