| Gene Symbol | PYCARD |
| Protein Family | PYD/CARD adaptor family |
| Protein Type | Signaling Protein |
| Target Class | Signaling Protein |
| Function | PYCARD functions as the central adaptor in inflammasome signaling. |
| Mechanism of Action | PYCARD acts as a critical adaptor protein in inflammasome activation, facilitating pro-inflammatory caspase-1 recruitment and subsequent IL-1β/IL-18 processing, which contributes to neuroinflammatory processes in neurodegenerative conditions like Alzheimer's and Parkinson's disease. Its protein-protein interaction domains mediate inflammatory signal transduction, potentially amplifying neuronal damage through excessive immune response activation. |
| Subcellular Localization | Cytoplasm (inflammasome specks) |
| Druggability | Low (0.35) |
| Clinical Stage | Phase II |
| Molecular Weight | 22 kDa |
| Amino Acids | 90 aa |
| Pathways | Apoptosis, Inflammasome, Inflammatory response, PANoptosis, Pyroptosis |
| UniProt ID | Q9ULZ3 |
| GeneCards | PYCARD |
| Human Protein Atlas | PYCARD |
| Associated Diseases | Aging, ALS, Alzheimer, Alzheimer's disease, Atherosclerosis, Cancer |
| Known Drugs/Compounds | rapamycin |
| Interactions | ACHE, ACTB, AGING, AIF1, AIM2, ALZHEIMER |
| SciDEX Target | View Target Profile (1 clinical trials) |
| KG Connections | 750 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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