protein 534 words KG: UNC13A
Contents

UNC13A Protein

🔬 Protein Info
Gene SymbolUNC13A
Full NameUnc-13 Homolog A
AliasesMunc13-1
Chromosome19p13.11
FunctionSynaptic vesicle priming factor essential for neurotransmitter release
Primary ExpressionPresynaptic terminals, Motor Neurons, Cortical Neurons, Hippocampus
Subcellular Localization</td><td>Synaptic vesicle presynaptic terminal</td></tr>
Molecular Weight194.3 kDa
Amino Acids1703
PathwaysSynaptic vesicle exocytosis, Neurotransmitter release
UniProt IDQ9UPW8
Ensembl IDENSG00000130477
GeneCardsUNC13A
Human Protein AtlasUNC13A
Associated DiseasesAls, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia, Depletion
InteractionsALS, ALZHEIMER, amyotrophic lateral sclerosis, AMYOTROPHIC LATERAL SCLEROSIS, DEMENTIA, NEURODEGENERATIVE DISEASES
KG Connections182 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (8)

Arginine Methylation Enhancement Therapy
Score: 0.65
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Cryptic Exon Silencing Restoration
Score: 0.53
PARP1 Inhibition Therapy
Score: 0.74
Cross-Seeding Prevention Strategy
Score: 0.69
Glycine-Rich Domain Competitive Inhibition
Score: 0.64
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed

See Also (15)

Alzheimer Indonesia
institution · KG edge: associated_with
ANO9 — Anoctamin 9
gene · KG edge: implicated_in
Packard Center for ALS Research
institution · KG edge: associated_with
Amyotrophic Lateral Sclerosis
redirect · KG edge: activates
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

Knowledge Graph (12 edges)

C3AR1 regulates UNC13A
RBPJL regulates UNC13A
UNC13A regulates ANO9
UNC13A regulates TBK1
TDP-43 regulates UNC13A
TDP-43 causes UNC13A
ALS-risk SNPs causes UNC13A
TDP43 causes UNC13A
ALS-risk SNPs associated_with UNC13A
UNC13A associated_with Depletion

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