Contents

TLR4 Protein

🔬 Protein Info

Gene Symbol	TLR4
Full Name	Toll-Like Receptor 4
Chromosome	9q33.1
Protein Type	Receptor
Target Class	Receptor
Function	LBP transfer: LPS-binding protein transfers LPS to CD14
Mechanism of Action	Small molecule antagonist or antibody blocking TLR4-mediated neuroinflammatory signaling
Subcellular Localization	</strong></td><td>Plasma membrane, endosomes</td></tr>
Druggability	Low (0.41)
Clinical Stage	Phase III
Molecular Weight	95 kDa
Pathways	Akt, Amyloid, Apoptosis, Autophagy, Cell Division
UniProt ID	O00206
NCBI Gene ID	7099
Ensembl ID	ENSG00000136869
OMIM	603030
GeneCards	TLR4
Human Protein Atlas	TLR4
Associated Diseases	Aging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	DHT, DOXORUBICIN, Ezetimibe, FREE HEME, Gastrodin, hesperetin
Interactions	ABETA, ACAT1, Actin, AD, AGING, AHR
SciDEX Target	View Target Profile (4 clinical trials)
SciDEX Hypotheses	Selective TLR4 Modulation to Prevent Gut-Derived N
KG Connections	2306 knowledge graph edges
Databases	GeneCards HPA STRING

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