protein 612 words KG: TGFBR1PROTEIN
Contents

TGF-beta Receptor 1 (TGFβR1) Protein

🔬 Protein Info
Gene SymbolTGF
Full Namebeta Receptor 1 (TGFβR1) Protein
Chromosome9q22.
FunctionTGF-β Receptor 1 (TGFBR1) is a transmembrane serine/threonine kinase that serves as the primary type I receptor for transforming growth factor-beta ligands in the nervous system.
Molecular Weight~56 kDa
Amino Acids503 amino acids
Pathwaysunfolded protein response, TGF-beta signaling, neurotrophin signaling, NF-kB signaling, oxidative stress response
GeneCardsTGF
Human Protein AtlasTGF
Length503 amino acids
Associated DiseasesALS, Alzheimer, Alzheimer's disease, cancer, cardiovascular disease, glioblastoma
Known Drugs/Compoundscurcumin, rapamycin
InteractionsADAMTS4, AKT, AMPK, ANGPT1, APP, AQP1
KG Connections251 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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UniProtWikipedia

Related Hypotheses (7)

Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Ocular Immune Privilege Extension
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (9)

Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

Related Experiments (11)

miRNomic profiling and TGF-β content analysis in sEV
exploratory · proposed · Score: 0.90
ROC curve analysis for predicting sEV ineffectiveness
clinical · proposed · Score: 0.90
ROC analysis for sEV effectiveness prediction
clinical · proposed · Score: 0.90
miRNomic profiling and TGF-β content analysis in sEV
exploratory · proposed · Score: 0.85
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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