protein 1,635 words KG: TGFB1PROTEIN
Contents

TGF-β1 Protein

🔬 Protein Info
Gene SymbolTGF
Full Nameβ1 Protein
FunctionTGF-β Receptor 1 (TGFBR1) is a transmembrane serine/threonine kinase that serves as the primary type I receptor for transforming growth factor-beta ligands in the nervous system.
Molecular Weight~56 kDa
Amino Acids503 amino acids
Pathwaysunfolded protein response, TGF-beta signaling, neurotrophin signaling, NF-kB signaling, oxidative stress response
GeneCardsTGF
Human Protein AtlasTGF
Associated DiseasesALS, Alzheimer, Alzheimer's disease, cancer, cardiovascular disease, glioblastoma
Known Drugs/Compoundscurcumin, rapamycin
InteractionsADAMTS4, AKT, AMPK, ANGPT1, APP, AQP1
KG Connections251 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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UniProtWikipedia

Related Hypotheses (7)

Ocular Immune Privilege Extension
Score: 0.69
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (8)

What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (11)

miRNomic profiling and TGF-β content analysis in sEV
exploratory · proposed · Score: 0.90
ROC curve analysis for predicting sEV ineffectiveness
clinical · proposed · Score: 0.90
ROC analysis for sEV effectiveness prediction
clinical · proposed · Score: 0.90
miRNomic profiling and TGF-β content analysis in sEV
exploratory · proposed · Score: 0.85
TREM2 Function in Alzheimer's Disease — From Risk Variant to
validation · proposed · Score: 0.45

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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