| Gene Symbol | TFE3 |
| Aliases | TFE3PROTEIN |
| Function | is a member of the MiT/TFE family of basic helix-loop-helix leucine zipper (bHLH-LZ) transcription factors, alongside TFEB, MITF, and TFEC. |
| Primary Expression | neurons, microglia, astrocytes, and oligodendrocytes - Double |
| Subcellular Localization | </td><td>Cytoplasm (inactive), Nucleus (active)</td></tr> |
| Molecular Weight | 59.5 kDa |
| Amino Acids | 575 aa |
| Pathways | mTOR, mtor |
| Ensembl ID | ENSG00000068323 |
| GeneCards | TFE3 |
| Human Protein Atlas | TFE3 |
| Lysosomal stress / starvation | Calcineurin (activated by lysosomal Ca2+ release via MCOLN1/TRPML1) dephosphorylates Ser321 |
| TFE3-TFE3 homodimers | Most common form; strong CLEAR element affinity |
| TFE3-TFEB heterodimers | Function cooperatively on shared target genes |
| TFE3-MITF heterodimers | Primarily in melanocytes and microglial cells |
| Associated Diseases | ALS, Alzheimer, Kidney Cancer, Multiple Sclerosis, neurodegeneration, Parkinson |
| Known Drugs/Compounds | rapamycin |
| Interactions | Actin, AGING, AKT, AKT1, AKT1S1, AKT2 |
| SciDEX Hypotheses | Selective TFEB Cofactor Enhancement |
| KG Connections | 608 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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