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SYNGAP1 — Synaptic Ras GTPase Activating Protein 1

🧬 Gene Info

Gene Symbol	SYNGAP1
Full Name	Synaptic Ras GTPase Activating Protein 1
Chromosome	6p21.3
Function	is a major postsynaptic density (PSD) protein that regulates Ras signaling and controls AMPA receptor trafficking, making it essential for synaptic plasticity, learning, and memory.
Primary Expression	Brain (cortex, hippocampus), postsynaptic densities
Molecular Weight	150 kDa
Amino Acids	1343 aa
UniProt ID	[Q9ULB0](https://www.uniprot.org/uniprot/Q9ULB0)
Ensembl ID	ENSG00000197283
OMIM	603384
GeneCards	SYNGAP1
Human Protein Atlas	SYNGAP1
N-terminal domain	Contains a C2 domain (Ca²⁺/lipid-binding)
PDZ-binding motif	Mediates interaction with PSD-95 and other scaffolding proteins
SH3 domain	Protein-protein interactions
Associated Diseases	neurodegeneration
Interactions	ERK, RAS, STXBP1
SciDEX Hypotheses	Interneuron SYNGAP1 Deficiency Disrupts Cortical C
KG Connections	18 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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