| Gene Symbol | STING1 |
| Aliases | STING1PROTEIN |
| Protein Type | Signaling Protein |
| Target Class | Signaling Protein |
| Function | DNA sensing: cGAS (cyclic GMP-AMP synthase) binds cytosolic dsDNA from any source — mitochondrial, nuclear, microbial, or retrotransposon-derived |
| Mechanism of Action | Small molecule agonists or antagonists of cGAS-STING pathway activation |
| Subcellular Localization | </td><td>Endoplasmic reticulum, ER-Golgi intermediate compartment, Golgi apparatus</td></tr> |
| Druggability | Low (0.40) |
| Clinical Stage | Phase II |
| Pathways | Akt, Autophagy, Immune Response, Wnt, innate_immune_response |
| UniProt ID | A0A494C1N5 |
| Ensembl ID | ENSG00000184584 |
| GeneCards | STING1 |
| Human Protein Atlas | STING1 |
| K63-linked ubiquitination | By TRIM56 and TRIM32, promotes STING activation |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | cGAMP, palmitic acid, Palmitic Acid, PA treatment, rapamycin, VS-X4 |
| Interactions | ABCD3, ACOX1, Actin, Adiponectin, ADIPOQ, AKT1 |
| SciDEX Target | View Target Profile (3 clinical trials) |
| SciDEX Hypotheses | Mitochondrial NAD+ Salvage Enhancement |
| KG Connections | 1279 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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