| Gene Symbol | PRKNPROTEIN |
| Full Name | Parkin |
| Protein Type | Protein |
| Function | is a critically important E3 ubiquitin ligase that plays a central role in mitochondrial quality control through mitophagy. |
| Subcellular Localization | Parkin family proteins that serves as a scaffold for protein interactions and co |
| UniProt ID | Search UniProt |
| GeneCards | PRKNPROTEIN |
| Human Protein Atlas | PRKNPROTEIN |
| RING0 domain (residues 141-188) | A unique domain found in Parkin family proteins that serves as a scaffold for protein interactions and contributes to the active site architecture. |
| RING1 domain (residues 212-277) | Contains the first RING finger motif that coordinates two zinc ions. This domain interacts with E2 ubiquitin-conjugating enzymes. |
| Associated Diseases | AD, Aging, ALI, Als, Alzheimer |
| Known Drugs/Compounds | dimethyl fumarate, FB231, Fumarate, nicotinamide, rapamycin |
| Interactions | ABCD3, ABP, ACTB, Actin, AIF1, AIFM1 |
| KG Connections | 1622 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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