protein 745 words KG: NFL
Contents

Neurofilament Light Chain (NF-L)

🔬 Protein Info
Gene SymbolNEFL
Full NameNeurofilament Light Polypeptide
Chromosome8p21.2
Protein FamilyIntermediate filament family
Functionis a neuronal intermediate filament protein encoded by the NEFL gene on chromosome 8p21.
Primary ExpressionCNS and PNS neurons (axons)
Molecular Weight~61.5 kDa
Amino Acids543 aa
Exons4
PathwaysAmyloid, ubiquitin-proteasome
UniProt IDP07196
NCBI Gene ID4747
Ensembl IDENSG00000104825
OMIM162280
GeneCardsNEFL
Human Protein AtlasNEFL
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOE
KG Connections274 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (21)

Senescent Microglia Resolution via Maresins-Senolytics Combi
Score: 0.79
Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Targeted Butyrate Supplementation for Microglial Phenotype M
Score: 0.70
Enhancing Vagal Cholinergic Signaling to Restore Gut-Brain A
Score: 0.67
Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.64
Vagal Afferent Microbial Signal Modulation
Score: 0.62
Blood-Brain Barrier SPM Shuttle System
Score: 0.53
Ocular Immune Privilege Extension
Score: 0.69
Microbial Inflammasome Priming Prevention
Score: 0.65
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
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Related Analyses (9)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · completed
Astrocyte Reactivity Subtypes in Neurodegeneration
neurodegeneration · archived
Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed

Related Experiments (4)

Lifestyle Intervention Mechanisms in Alzheimer's Disease
validation · proposed · Score: 0.40
NPH Glymphatic System Interaction Experiment
clinical · proposed · Score: 0.40
PSP and CBS Biomarker Validation Study
clinical · proposed · Score: 0.40
Viral Infections and Alzheimer's Disease — causal mechanisms
clinical · proposed · Score: 0.40

See Also (15)

Alzheimer Indonesia
institution · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Packard Center for ALS Research
institution · KG edge: associated_with
Amyotrophic Lateral Sclerosis
redirect · KG edge: associated_with
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 3 hypotheses

Knowledge Graph (12 edges)

UCHL1 interacts_with NFL
GFAP interacts_with NFL
TMEM119 interacts_with NFL
SYNAPTOPHYSIN biomarker_for NFL
BACE1 biomarker_for NFL
NFL interacts_with GFAP
NFL biomarker_for BACE1
NFL biomarker_for NEUROGRANIN
NFL biomarker_for TAU
SOD1 associated_with NFL

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