| Gene Symbol | NRBP1 |
| Full Name | Nuclear Receptor Binding Protein 1 |
| Aliases | Page for NRBP1 |
| Protein Type | Receptor |
| Function | NRBP1 (Nuclear Receptor Binding Protein 1) is a conserved eukaryotic protein that functions as a transcriptional co-regulator and scaffold protein. |
| Pathways | NF-κB, WNT, wnt, MAPK |
| Ensembl ID | ENSG00000130726 |
| GeneCards | NRBP1 |
| Human Protein Atlas | NRBP1 |
| Cell Signaling Hub | NRBP1 integrates signals from multiple pathways including NF-κB, WNT, and MAPK cascades. It modulates downstream transcriptional outputs in response to cellular stress. |
| Cell Cycle Regulation | The protein participates in cell cycle control through interactions with cyclin-dependent kinases and cell cycle regulators. Dysregulation can lead to abnormal proliferation or cell death. |
| Mitochondrial Function | NRBP1 localizes to mitochondria under stress conditions and influences mitochondrial dynamics, apoptosis, and cellular energy metabolism. |
| Brain | Cortex, hippocampus, basal ganglia |
| Liver and kidney | High metabolic activity tissues |
| Pancreas | Islet cells |
| Associated Diseases | depression |
| Known Drugs/Compounds | R-ketamine |
| Interactions | Actin, AND, Bdnf, BDNF, CREB, CSF1R |
| KG Connections | 58 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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