| Gene Symbol | LIMK1 |
| Protein Type | Serine/Threonine Kinase |
| Function | LIMK1 is a key regulator of actin dynamics |
| Primary Expression | the brain, particularly in regions involved in learning and memory, and is implicated in synaptic plasticity, neuronal development, and various neurod |
| Molecular Weight | 72 kDa |
| Pathways | Nf-Κb, Apoptosis, Toll-Like Receptor, Blood-Brain Barrier, unfolded protein response |
| GeneCards | LIMK1 |
| Human Protein Atlas | LIMK1 |
| LIM domain | Zinc-binding domain at N-terminus involved in protein-protein interactions |
| PDZ domain | Scaffold for signaling complexes |
| Kinase domain | Catalytic serine/threonine kinase domain at C-terminus |
| Rho GTPases | Rac1 and Cdc42 activate LIMK1 via PAK kinases |
| Phosphorylation | Autophosphorylation and activation by PAK1/PAK4 |
| Associated Diseases | Alzheimer, Encephalitis, Multiple Sclerosis, Neuronal Structural Alterations |
| Interactions | ALZHEIMER, ALZHEIMER'S DISEASE, AND, CD55, CFH, Cofilin |
| KG Connections | 71 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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