protein 888 words KG: HSP90
Contents

HSP90 Protein (Heat Shock Protein 90)

🔬 Protein Info
Gene SymbolHSP90
AliasesHeat Shock Protein 90
Protein TypeChaperone
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight90 kDa
Amino Acids220 aa
PathwaysApoptosis, Autophagy, Chaperone, Oxidative Stress
GeneCardsHSP90
Human Protein AtlasHSP90
Associated DiseasesALS, Alzheimer's disease, Depression, HUNTINGTON, HUNTINGTON'S
Known Drugs/Compounds17-AAG
InteractionsAD, AGING, AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections615 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (23)

HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor
Score: 0.54
HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57
Circadian-Synchronized Proteostasis Enhancement
Score: 0.74
PARP1 Inhibition Therapy
Score: 0.74
Proteostasis Enhancement via APOE Chaperone Targeting
Score: 0.72
Membrane Cholesterol Gradient Modulators
Score: 0.71
CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
Multi-Modal Stress Response Harmonization
Score: 0.76
Smartphone-Detected Motor Variability Correction
Score: 0.74
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Retinal Vascular Microcirculation Rescue
Score: 0.72
Ocular Immune Privilege Extension
Score: 0.69
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Related Analyses (15)

What are the minimal structural requirements for HSP70/HSP90
drug discovery · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · completed

Related Experiments (20)

s:** - Compare tau strain spreading in EXT1/EXT2 conditional
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
AKT1 Gene
gene · KG edge: causes
APE2 Gene
gene · KG edge: binds
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

HSP90 expressed_in Schwann Cell
FYN interacts_with HSP90
APOE4 co_discussed HSP90
HSP90 co_discussed TAU
HSP70 co_discussed HSP90
CDC37 interacts_with HSP90
PINK1 regulates HSP90
GPX4 inhibits HSP90
RIPK1 inhibits HSP90
HSP90 inhibits TNF

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