protein 888 words KG: HSP90
Contents

HSP90 Protein (Heat Shock Protein 90)

🔬 Protein Info
Gene SymbolHSP90
AliasesHeat Shock Protein 90
Protein TypeChaperone
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight90 kDa
Amino Acids220 aa
PathwaysApoptosis, Autophagy, Chaperone, Oxidative Stress
GeneCardsHSP90
Human Protein AtlasHSP90
Associated DiseasesALS, Alzheimer's disease, Depression, HUNTINGTON, HUNTINGTON'S
Known Drugs/Compounds17-AAG
InteractionsAD, AGING, AKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections608 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (23)

Pharmacological Enhancement of APOE4 Glycosylation
Score: 0.62
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55
Vocal Cord Neuroplasticity Stimulation
Score: 0.52
← Prevpg 2/2

Related Analyses (15)

What are the minimal structural requirements for HSP70/HSP90
drug discovery · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · completed

Related Experiments (20)

s:** - Compare tau strain spreading in EXT1/EXT2 conditional
falsification · proposed · Score: 0.40
s:** - Dose-response studies showing therapeutic window with
falsification · proposed · Score: 0.40
4R-Tau Targeting Therapies for PSP and CBS
clinical · proposed · Score: 0.40
Computational Modeling of Alpha-Synuclein Propagation in PD
validation · proposed · Score: 0.40
Anti-Tau Immunotherapy Dosing Optimization
clinical · proposed · Score: 0.40

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: inhibits
AKT1 Gene
gene · KG edge: causes
APE2 Gene
gene · KG edge: binds
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

HSP90 expressed_in Schwann Cell
FYN interacts_with HSP90
APOE4 co_discussed HSP90
HSP90 co_discussed TAU
HSP70 co_discussed HSP90
CDC37 interacts_with HSP90
PINK1 regulates HSP90
GPX4 inhibits HSP90
RIPK1 inhibits HSP90
HSP90 inhibits TNF

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