| Gene Symbol | GPX4 |
| Full Name | Glutathione Peroxidase 4 |
| Aliases | GPX4PROTEIN |
| Chromosome | 19p13.3 |
| Protein Type | Enzyme |
| Target Class | Enzyme |
| Function | GPX4 serves as the primary defense against lipid peroxidation in cellular membranes |
| Mechanism of Action | Small molecule inhibitor or activator of peroxidase activity |
| Subcellular Localization | </b></td><td>Cytosol, mitochondria, nucleus</td></tr> |
| Druggability | Low (0.41) |
| Clinical Stage | Phase II |
| Molecular Weight | 22 kDa |
| Pathways | Akt, Apoptosis, Autophagy, Differentiation, Epigenetic |
| UniProt ID | P36969 |
| Ensembl ID | ENSG00000167468 |
| GeneCards | GPX4 |
| Human Protein Atlas | GPX4 |
| Associated Diseases | Als, Alzheimer, Cancer, Carcinoma, Copd |
| Known Drugs/Compounds | curcumin, CURCUMIN, icariin, N-ACETYLCYSTEINE, NICOTINAMIDE, paricalcitol |
| Interactions | ACETYL-COA, ACHE, ACSL4, ACTB, AD, AGING |
| SciDEX Target | View Target Profile (10 clinical trials) |
| SciDEX Hypotheses | GPX4 reserve failure gates selective ALS motor-neu Ferroptosis Inhibition for α-Synuclein Neuroprotec GPX4 Selenopeptide Mimetics as Neuroprotective Fer (+1 more) |
| KG Connections | 2266 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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