| Gene Symbol | EAAT2 |
| Aliases | EAAT2PROTEIN |
| Function | EAAT2 (also known as GLT-1 or SLC1A2) is a 574-amino acid transmembrane protein that functions as the primary glutamate transporter in the brain. |
| Subcellular Localization | Plasma membrane, astrocytic processes ensheathing synapses ; Protein Family : Ex |
| Molecular Weight | 65 kDa |
| Amino Acids | 574 aa |
| Pathways | neurotrophin signaling, glutamate signaling, circadian regulation, Tau Phosphorylation |
| GeneCards | EAAT2 |
| Human Protein Atlas | EAAT2 |
| 8 transmembrane domains | Core structural elements |
| Hairpin loops | Two re-entrant loops (HP1 and HP2) that form the substrate translocation pathway |
| Trimer assembly | Functions as a homotrimer, each subunit capable of independent transport |
| Substrate binding site | Located within the central cavity formed by the trimer |
| Glutamate clearance | Removes ~80% of synaptic glutamate after release [1] |
| Excitotoxicity prevention | Prevents excessive glutamate accumulation [1] |
| Associated Diseases | ALS, Alzheimer, epilepsy, neurodegeneration, Parkinson |
| Known Drugs/Compounds | memantine, rapamycin |
| Interactions | ALZHEIMER, AQP4, BDNF, BMAL1, CREB, GABA |
| KG Connections | 97 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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