| Gene Symbol | PIK3CA |
| Chromosome | 3q26.32 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 120 kDa |
| Amino Acids | 068 aa |
| Exons | 21 |
| Pathways | PI3K, mTOR |
| GeneCards | PIK3CA |
| Human Protein Atlas | PIK3CA |
| Adaptor-binding domain (ABD) | Residues 1-108, mediates interaction with p85 regulatory subunit |
| C2 domain | Residues 170-270, membrane targeting and lipid binding |
| Helical domain | Residues 330-600, regulatory interactions |
| Kinase domain | Residues 700-1068, catalytic activity (phosphoinositide 3-kinase) |
| Associated Diseases | Aging, Als, Breast cancer |
| Known Drugs/Compounds | Alpelisib, Apitolisib, Chrysotoxine, Paxalisib, rapamycin |
| Interactions | ACVR1, AKT, AKT1, AKT3, APOPTOSIS, App |
| KG Connections | 724 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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