| Gene Symbol | NTRK1 |
| Function | Trka (Tropomyosin Receptor Kinase A) (Ntrk1) plays an important role in the study of neurodegenerative diseases. |
| Molecular Weight | 87 kDa |
| Amino Acids | 796 aa |
| GeneCards | NTRK1 |
| Human Protein Atlas | NTRK1 |
| Activation | Autophosphorylation of TrkA creates docking sites for PI3K adaptor proteins (e.g., Shc, IRS-1) |
| PI3K activation | Generates phosphatidylinositol (3,4,5)-trisphosphate (PIP3) |
| Akt activation | PIP3 recruits Akt to the membrane where it is phosphorylated and activated |
| Survival effects | Akt phosphorylates and inhibits pro-apoptotic proteins (Bad, caspase-9) |
| Metabolic regulation | Akt promotes glucose metabolism and protein synthesis |
| Neuronal differentiation | Promotes neurite outgrowth and dendritic arborization |
| Synaptic plasticity | Modifies synaptic strength and structure |
| Gene expression | Activates transcription factors (e.g., CREB) that promote neuronal survival |
| Cell cycle | ERK1/2 activation can support neuronal survival under certain conditions |
| Associated Diseases | disease, Glioma |
| Interactions | AKT, CCT5, PDGFRA, RAB7, SPTLC1 |
| KG Connections | 27 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!
No comments yet. Be the first to comment!