protein 745 words KG: NFL
Contents

Neurofilament Light Chain (NF-L)

🔬 Protein Info
Gene SymbolNEFL
Full NameNeurofilament Light Polypeptide
Chromosome8p21.2
Protein FamilyIntermediate filament family
Functionis a neuronal intermediate filament protein encoded by the NEFL gene on chromosome 8p21.
Primary ExpressionCNS and PNS neurons (axons)
Molecular Weight~61.5 kDa
Amino Acids543 aa
Exons4
PathwaysAmyloid, ubiquitin-proteasome
UniProt IDP07196
NCBI Gene ID4747
Ensembl IDENSG00000104825
OMIM162280
GeneCardsNEFL
Human Protein AtlasNEFL
Associated DiseasesAging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia
InteractionsALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYOTROPHIC LATERAL SCLEROSIS, AND, APOE
KG Connections274 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

UniProtWikipedia

Related Hypotheses (1)

Cerebrospinal NFL-Triggered Liposome Dosing Maximizes lncRNA
Score: 0.52

Knowledge Graph (12 edges)

UCHL1 interacts_with NFL
GFAP interacts_with NFL
TMEM119 interacts_with NFL
SYNAPTOPHYSIN biomarker_for NFL
BACE1 biomarker_for NFL
NFL interacts_with GFAP
NFL biomarker_for BACE1
NFL biomarker_for NEUROGRANIN
NFL biomarker_for TAU
SOD1 associated_with NFL

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