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mechanism 1,721 words KG: Ros
Contents

Metal Ion-Synuclein-Mitochondria (MISM) Axis in Parkinson's Disease

⚙ Mechanism Info
NameRos
Key Genes/ProteinsAKT, DNM1L, FOXO3, HIF1, KRAS, MAPK14
Related DiseasesIKK activation, Inflammatory Bowel Disease

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Related Hypotheses (33)

TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Smartphone-Detected Motor Variability Correction
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Score: 0.74Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74APOE-TREM2 Interaction Modulation
Score: 0.74SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration
Score: 0.70Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70Mitochondrial Transfer Pathway Enhancement
Score: 0.70CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67Mitochondrial RNA Granule Rescue Pathway
Score: 0.66The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65Mitochondrial Calcium Buffering Enhancement via MCU Modulati
Score: 0.65Mitochondrial SPM Synthesis Platform Engineering
Score: 0.65Targeting Bacterial Curli Fibrils to Prevent α-Synuclein Cro
Score: 0.64Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62Metabolic Reprogramming via Coordinated Multi-Gene CRISPR Ci
Score: 0.60
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Related Analyses (30)

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neurodegeneration · archivedSynaptic pruning by microglia in early AD
neurodegeneration · archivedMitochondrial transfer between astrocytes and neurons
neurodegeneration · archivedEpigenetic clocks and biological aging in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

TREM2 Agonist Therapy for Parkinson's Disease — Experimental
validation · proposed · Score: 0.45Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson
clinical · proposed · Score: 0.40Axonal Transport Dysfunction Validation in Parkinson's Disea
clinical · proposed · Score: 0.40AAV Serotype Comparison for LRRK2 Knockdown in PD Gene Thera
validation · proposed · Score: 0.40AAV-LRRK2 IND-Enabling Study Design
clinical · proposed · Score: 0.40

Knowledge Graph (12 edges)

Ros activates FOXO3
Ros activates NRF2
P62 downregulates Ros
AKT modulates Ros
Ros phosphorylates DNM1L
Ros cleaves OPA1
Ros activates MAPK8
Ros activates MAPK3
TNF involved_in Ros
Nac inhibits Ros

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