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mechanism 1,212 words KG: GLUTAMATE
Contents

Glutamate Signaling Pathway

⚙ Mechanism Info
NameGLUTAMATE
Key Genes/ProteinsABCA7, ADRA2B, AKT, ALZHEIMER, AMPA RECEPTOR, AMPK
Related Diseasesacetylcholine, ACETYLCHOLINE, ALS, Alzheimer'S Disease, ALZHEIMER'S DISEASE
Related PathwaysAMPK SIGNALING

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Related Hypotheses (108)

Ephrin-B2/EphB4 Axis Manipulation
Score: 0.64TREM2-mediated microglial tau clearance enhancement
Score: 0.62Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.61Netrin-1 Gradient Restoration
Score: 0.59VCP-Mediated Autophagy Enhancement
Score: 0.59TREM2-Mediated Selective Aggregate Clearance Pathway
Score: 0.58Synaptic Vesicle Tau Capture Inhibition
Score: 0.58HSP90-Tau Disaggregation Complex Enhancement
Score: 0.57Gut Barrier Permeability-α-Synuclein Axis Modulation
Score: 0.53Enteric Nervous System Prion-Like Propagation Blockade
Score: 0.48Optogenetic Control of Mitochondrial Transfer Networks
Score: 0.48Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43Gap Junction Hemichannel Modulation for Controlled Mitochond
Score: 0.36Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.95AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.83Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.78Prefrontal sensory gating circuit restoration via PV interne
Score: 0.78
← Prevpg 3/6Next →

Related Analyses (30)

Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedTau propagation mechanisms and therapeutic interception poin
neurodegeneration · archivedEpigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (1)

Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (4)

acetylcholine
general · KG edge: co_discussedadra2b Gene
gene · KG edge: expressed_inAlzheimer Indonesia
institution · KG edge: activatesPackard Center for ALS Research
institution · KG edge: associated_with

Knowledge Graph (12 edges)

GLUTAMATE associated_with EXCITOTOXICITY
MACROPHAGES activates GLUTAMATE
GLUTAMATE inhibits AXONS
GLUTAMATE causes EXCITOTOXICITY
FERROPTOSIS co_discussed GLUTAMATE
GLUTAMATE co_discussed GPX4
GLUTAMATE co_discussed MITOCHONDRIA
BRAINSTEM co_discussed GLUTAMATE
FOXO3 co_discussed GLUTAMATE
GLUTAMATE co_discussed OPTN

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