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mechanism 1,441 words KG: CREB
Contents

CREB-Independent Neuronal Survival Pathways in Neurodegeneration

⚙ Mechanism Info
NameCREB
Key Genes/ProteinsABETA, ACAT1, ACETYL-COA, ACHE, ACOX1, Actin
Related DiseasesAging
Linked Hypotheses14 hypotheses

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🌐 Cross-references

Wikipedia

Related Hypotheses (153)

The Glial Ketone Metabolic Shunt Hypothesis
Score: 0.61PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor
Score: 0.53APOE-Dependent Autophagy Restoration
Score: 0.89Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK
Score: 0.74TREM2-mediated microglial tau clearance enhancement
Score: 0.62LRP1-Dependent Tau Uptake Disruption
Score: 0.60Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60Synaptic Vesicle Tau Capture Inhibition
Score: 0.58Context-Dependent CRISPR Activation in Specific Neuronal Sub
Score: 0.68Programmable Neuronal Circuit Repair via Epigenetic CRISPR
Score: 0.63
← Prevpg 8/8

Related Analyses (30)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived

Related Experiments (30)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40Proposed experiment from debate on Astrocytes adopt A1 (neur
falsification · proposed · Score: 0.40s:** - Biochemical binding assays measuring PROTAC selectivi
falsification · proposed · Score: 0.40Proposed experiment from debate on Epigenetic clocks and bio
falsification · proposed · Score: 0.40Proposed experiment from debate on Microglia activate astroc
falsification · proposed · Score: 0.40

See Also (15)

Beta-Propeller Protein-Associated Neurodegeneration (BP
disease · Pages share 139 hypothesesChina Neurodegeneration Epidemiology
disease · Pages share 139 hypothesesNeuroimaging for Parkinsonian Syndromes (NCT03872102)
clinical · Pages share 27 hypothesesSynaptic Biomarkers in Neurodegeneration
biomarker · Pages share 139 hypothesesOlfactory Mucosa, Blood and Urine for Identification of
clinical · Pages share 139 hypotheses

Knowledge Graph (12 edges)

ALS associated_with CREB
CREB associated_with frontotemporal dementia
CREB associated_with NLRP3
CREB interacts_with PI3K
CREB interacts_with PKA
CREB interacts_with ERK
CREB regulates BDNF
cAMP activates CREB
CREB regulates BDNF_GENE
CREB activates BDNF_MRNA

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