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Gap: Research Priorities in Neurodegenerative Disease
gap
2,929 words
KG: ALS
Contents
Research Priorities in Neurodegenerative Disease
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Knowledge Graph
Related Hypotheses (19)
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43
Score: 0.82
STING Antagonists as ALS Therapeutics: Drug Repurposing
Score: 0.74
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A
Score: 0.66
SPP1+ DAM as Source of Autoimmunity in Neurodegeneration
Score: 0.66
Galectin-3 deletion attenuates NLRP3 inflammasome activation
Score: 0.65
ALS-Linked OPTN/TBK1 Mutations Impair Phosphorylation Cascad
Score: 0.65
Nuclear TDP-43 Depletion Drives Synaptic Splicing Dysregulat
Score: 0.62
ALS-Associated G3BP1 Mutations Shift Phase Separation Equili
Score: 0.61
Aberrant Galectin-3 Expression on Stressed Synapses Creates
Score: 0.60
Aβ42 oligomers drive TDP-43 phosphorylation at s409/410 thro
Score: 0.59
ALS-Associated G3BP1/2 Mutations Disrupt TRIM21 Binding Inte
Score: 0.58
PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5
Score: 0.58
C9orf72-SMCR8-WDR41 Complex Dysfunction in C9-ALS Rescued by
Score: 0.56
H63D HFE Genotype-Guided Iron Chelation Therapy for Subset-S
Score: 0.55
N-acetylation Deficiency as Novel Metabolic Vulnerabilities
Score: 0.54
CSF1R Partial Agonism Combined with TREM2 Activation for ALS
Score: 0.54
FUS-ALS-Specific Ferroptosis Vulnerability Through NCOA4-Med
Score: 0.48
Age-dependent downregulation of KPNA2 creates limbic neuron-
Score: 0.45
ITGAX/CD11c Targeting to Eliminate Pro-inflammatory DAM in A
Score: 0.41
Show 14 more
Related Analyses (5)
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completed
Knowledge Graph (12 edges)
MIRO1
associated_with
ALS
ALS
associated_with
CMT
ALS
disrupts
axonal_transport
ALS
disrupts
protein_homeostasis
ALS
disrupts
RNA_metabolism
ALS
disrupts
mitochondrial_function
ALS
disrupts
cellular_stress_response
ALS
associated_with
HNRNPA2B1
ALS
associated_with
TDP-43
ALS
associated_with
GFAP
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