| Gene Symbol | TBK1 |
| Full Name | Mediated Neuroinflammation Hypothesis: Autophagy Failure Drives FTD/ALS |
| Chromosome | 12q14.2 |
| Protein Type | Serine/Threonine Kinase |
| Function | TBK1 belongs to the IκB kinase (IKK) subfamily of kinases, originally characterized for its role in activating innate immune signaling through the induction of type I interferons in response to viral |
| Primary Expression | Motor cortex, Spinal cord, Immune cells |
| Molecular Weight | 84 kDa |
| Pathways | Apoptosis, Autophagy, Epigenetic, Er Stress, Immune Response |
| UniProt ID | Q9UHD2 |
| NCBI Gene ID | 29110 |
| Ensembl ID | ENSG00000183735 |
| OMIM | 604834 |
| GeneCards | TBK1 |
| Human Protein Atlas | TBK1 |
| Associated Diseases | Aging, Als, Alzheimer, Alzheimer's disease, amyotrophic lateral sclerosis |
| Known Drugs/Compounds | amlexanox, rapamycin |
| Interactions | Actin, AGING, AIM2, AKT, AKT1, ALS |
| SciDEX Hypotheses | TBK1 Loss-of-Function Amplifies C1q-Mediated Synap TBK1 Phosphorylation State Creates Phospho-Regulat (+1 more) |
| KG Connections | 1280 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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