Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL17: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | IL17 |
| Key Genes/Proteins | IL1B, IL6, MTOR, NFKB |
| Related Diseases | Cognitive Impairment |
| Related Pathways | apoptosis pathway |
Knowledge base pages for this entity
graph TD
IL17["IL17"]
IL17 -->|"product_of"| Th17_Cell["Th17 Cell"]
IL17 -->|"mediates"| Immune_Cell_Recruitment["Immune Cell Recruitment"]
IL17 -->|"promotes"| Skeletal_Muscle_Inflammation["Skeletal Muscle Inflammation"]
IL17 -->|"expressed in"| Neutrophils["Neutrophils"]
IL17 -->|"expressed in"| Microglia["Microglia"]
IL17 -->|"expressed in"| Neutrophil["Neutrophil"]
IL17 -->|"upregulates"| IL1B["IL1B"]
IL17 -->|"upregulates"| IL6["IL6"]
Anti_Il_17_Antibody["Anti-Il-17 Antibody"] -->|"inhibits"| IL17
Chemokines["Chemokines"] -->|"involved_in"| IL17
MTOR["MTOR"] -->|"regulates"| IL17
S100A9["S100A9"] -->|"activates"| IL17| Target | Relation | Type | Str |
|---|---|---|---|
| Skeletal Muscle Inflammation | promotes | disease | 0.95 |
| Th17 Cell | product_of | cell_type | 0.95 |
| Immune Cell Recruitment | mediates | process | 0.95 |
| Myeloid Cell Immune Response | involved_in | process | 0.90 |
| Neutrophils | expressed_in | cell_type | 0.90 |
| Microglia | expressed_in | cell_type | 0.90 |
| Neutrophil | expressed_in | cell_type | 0.90 |
| IL1B | upregulates | gene | 0.85 |
| IL6 | upregulates | gene | 0.85 |
| TNF | upregulates | gene | 0.85 |
| rosacea | associated_with | disease | 0.85 |
| Cognitive Impairment | associated_with | phenotype | 0.85 |
| Immunity | regulates | process | 0.70 |
| NFKB | activates | protein | 0.68 |
| IL6 | expressed_in | gene | 0.60 |
| IL6 | activates | gene | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Anti-Il-17 Antibody | inhibits | drug | 0.95 |
| Chemokines | involved_in | compound | 0.80 |
| MTOR | regulates | protein | 0.70 |
| SEPSIS | activates | disease | 0.65 |
| S100A9 | activates | protein | 0.64 |
| quercetin | targets | drug | 0.60 |
| SEPSIS | associated_with | disease | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning IL17 in their description or question text
No additional research found