Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IKB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | IKB |
| Key Genes/Proteins | APOPTOSIS, BAX, BCL-2, CAT, ERK1, FOXO1 |
| Related Diseases | Ulcerative Colitis |
| Related Pathways | Apoptosis, Nf-Kb |
Knowledge base pages for this entity
graph TD
IKB["IKB"]
IKB -->|"activates"| NF_KB["NF-KB"]
IKB -->|"activates"| ERK1["ERK1"]
IKB -->|"activates"| APOPTOSIS["APOPTOSIS"]
IKB -->|"activates"| P38["P38"]
IKB -->|"activates"| FOXO1["FOXO1"]
IKB -->|"activates"| BCL_2["BCL-2"]
IKB -->|"activates"| Apoptosis["Apoptosis"]
IKB -->|"activates"| Nf_Kb["Nf-Kb"]
BAX["BAX"] -->|"inhibits"| IKB
BCL_2 -->|"inhibits"| IKB
TNF["TNF"] -->|"implicated in"| IKB
CAT["CAT"] -->|"implicated in"| IKB
TNF__["TNF-Alpha"] -->|"implicated in"| IKB| Target | Relation | Type | Str |
|---|---|---|---|
| NFKB | interacts_with | protein | 0.95 |
| Ulcerative Colitis | associated_with | disease | 0.65 |
| Nf-Kb | associated_with | pathway | 0.60 |
| Apoptosis | associated_with | pathway | 0.60 |
| NF-KB | activates | gene | 0.60 |
| ERK1 | activates | gene | 0.60 |
| APOPTOSIS | activates | gene | 0.60 |
| P38 | activates | gene | 0.60 |
| FOXO1 | activates | gene | 0.60 |
| BCL-2 | activates | gene | 0.60 |
| Apoptosis | activates | pathway | 0.60 |
| Nf-Kb | activates | pathway | 0.60 |
| NFKB | regulates | gene | 0.56 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning IKB in their description or question text
No additional research found