| Gene Symbol | UCHL1 |
| Chromosome | 4p14 |
| Protein Type | Enzyme |
| Function | is a highly abundant neuronal deubiquitinating enzyme that constitutes 1-5% of total brain protein. |
| Primary Expression | Cytoplasmic, enriched in axons and synaptic terminals |
| Subcellular Localization | Cytoplasmic, enriched in axons and synaptic terminals |
| Molecular Weight | 24.8 kDa |
| Amino Acids | 223 aa |
| Exons | 9 |
| Pathways | Angiogenesis, Autophagy, Ferroptosis, Glycolysis, Neural Stem Cell Maintenance |
| GeneCards | UCHL1 |
| Human Protein Atlas | UCHL1 |
| Strong neuronal promoter | Lacks TATA box, has multiple transcription start sites |
| Highly conserved | 95%+ amino acid identity across mammals |
| Alternative splicing | Produces multiple transcript variants |
| Associated Diseases | Ataxia, Ms, neurodegeneration, Neurodegenerative Diseases, traumatic brain injury |
| Interactions | A2M, ANGPT1, ATXN3, AUTOPHAGY, BCHE, CANCER |
| KG Connections | 177 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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