gene 1,612 words KG: SPTLC2
Contents

SPTLC2 Gene

🧬 Gene Info
Gene SymbolSPTLC2
Full NameSerine Palmitoyltransferase Long Chain Base Subunit 2
Chromosome14q31.3
Function### Serine Palmitoyltransferase Activity
Primary Expressionvarious brain regions:
Molecular Weight62 kDa
Amino Acids422 aa
Exons12
UniProt IDO15270
NCBI Gene ID9517
Ensembl IDENSG00000166800
OMIM610313
GeneCardsSPTLC2
Human Protein AtlasSPTLC2
Associated DiseasesNeuropathy
InteractionsADRA2A, ALDH1A2, ALS, GENES, IDH1, IRS1
KG Connections45 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (8)

APOE-Mediated Synaptic Lipid Raft Stabilization
Score: 0.65
Noradrenergic-Tau Propagation Blockade
Score: 0.71
CYP46A1 Overexpression Gene Therapy
Score: 0.95
Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.95
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Sphingomyelin Synthase Activators for Raft Remodeling
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69
Sphingolipid Metabolism Reprogramming
Score: 0.62

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (8)

Clusterin (ApoJ) - AD Biomarker
biomarker · KG edge: co_discussed
Hippocampal CA1 Pyramidal Neurons
cell · KG edge: expressed_in
Genes
index · KG edge: activates
ABCA1 - ATP-Binding Cassette Transporter A1
gene · KG edge: regulates
SPTLC1 - Serine Palmitoyltransferase
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

CLUSTERIN co_discussed SPTLC2
SPTLC1 activates SPTLC2
SPTLC2 expressed_in SPTLC1
SPTLC2 regulates SPTLC1
SPTLC2 regulates ABCA1
SPTLC1 expressed_in SPTLC2
ABCA1 regulates SPTLC2
SPTLC2 interacts_with SPTLC1
SPTLC1 regulates SPTLC2
SPTLC2 expressed_in Rb

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